INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00102905" target="_blank" >RIV/00216224:14110/18:00102905 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS

Popis výsledku v původním jazyce

G-quadruplex DNA (G4) has been known to be involved in many physiological processes in the cell e.g., in the promoter regions of oncogenes or in the human telomeric region. Because of their supposed role in cancer, G4 are often studied as targets for anti-cancer drugs. Natural and/or synthetic compounds, which are able to selectively bind these structures, have been intensively tested by means of molecular spectrometry, circular dichroism, equilibrium dialysis, and mass spectrometry. Compounds may interact with G4 by several mechanisms with various affinities. An approach to study a great number of potential effective compounds relies on combination of methods when relatively fast; however, imprecise mass spectrometry was used to preselect compounds, which were then subjected to more precise techniques studying G4 in a solution.

Název v anglickém jazyce

INTERACTION OF INTRAMOLECULAR G-QUADRUPLEX DNA STRUCTURES WITH SELECTED ALKALOIDS

Popis výsledku anglicky

G-quadruplex DNA (G4) has been known to be involved in many physiological processes in the cell e.g., in the promoter regions of oncogenes or in the human telomeric region. Because of their supposed role in cancer, G4 are often studied as targets for anti-cancer drugs. Natural and/or synthetic compounds, which are able to selectively bind these structures, have been intensively tested by means of molecular spectrometry, circular dichroism, equilibrium dialysis, and mass spectrometry. Compounds may interact with G4 by several mechanisms with various affinities. An approach to study a great number of potential effective compounds relies on combination of methods when relatively fast; however, imprecise mass spectrometry was used to preselect compounds, which were then subjected to more precise techniques studying G4 in a solution.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů