Wound heal­­ing ef­fects after application of polyunsaturated fatty acids in rat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F18%3A00104972" target="_blank" >RIV/00216224:14110/18:00104972 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.14735/amcsnn2018S29" target="_blank" >http://dx.doi.org/10.14735/amcsnn2018S29</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2018S29" target="_blank" >10.14735/amcsnn2018S29</a>

Jazyk výsledku

slovinština

Název v původním jazyce

Wound healing effects after application of polyunsaturated fatty acids in rat

Popis výsledku v původním jazyce

Introduction: Although mechanisms of polyunsaturated fatty acids influence on skin wound heal- ing have not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. Aim: The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Materials and methods: Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3 : omega-6 : omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Results: Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Conclusion: Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.

Název v anglickém jazyce

Wound heal­­ing ef­fects after application of polyunsaturated fatty acids in rat

Popis výsledku anglicky

Although mechanisms of fatty acids influence on skin wound healing has not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3:omega-6:omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

1802-4041

Svazek periodika

81

Číslo periodika v rámci svazku

Suppl. 1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

3

Strana od-do

„S29“-„S31“

Kód UT WoS článku

000452867800005

EID výsledku v databázi Scopus

2-s2.0-85093882666