The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108461" target="_blank" >RIV/00216224:14110/19:00108461 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/19:00070888

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.blre.2018.11.003" target="_blank" >http://dx.doi.org/10.1016/j.blre.2018.11.003</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.blre.2018.11.003" target="_blank" >10.1016/j.blre.2018.11.003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

Popis výsledku v původním jazyce

Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-kappa B pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-kappa B pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-kappa B pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-kappa B for myeloma cells, however, is used against them, as current treatment strategies often use NF-kappa B as their primary or secondary target.

Název v anglickém jazyce

The impact of NF-kappa B signaling on pathogenesis and current treatment strategies in multiple myeloma

Popis výsledku anglicky

Multiple myeloma, which ranks as the second most common hematological malignancy, is known for its great genetic heterogeneity. One pathway, however, stands out in this diverse group. NF-kappa B pathway is one of the most important pathways in multiple myeloma not only for its role in pathogenesis, but also for its importance in various treatment strategies. Mutations in several major components of the NF-kappa B pathway and its regulators are present in at least 17% of primary multiple myeloma tumors and 42% of multiple myeloma cell lines. The NF-kappa B pathway regulates numerous genes, which influence development and pathogenesis of multiple myeloma. This significance of NF-kappa B for myeloma cells, however, is used against them, as current treatment strategies often use NF-kappa B as their primary or secondary target.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

<a href="/cs/project/NV15-29508A" target="_blank" >NV15-29508A: Cirkulující nukleové kyseliny jako markery progrese mnohočetného myelomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BLOOD REVIEWS

ISSN

0268-960X

e-ISSN

1532-1681

Svazek periodika

34

Číslo periodika v rámci svazku

MAR 2019

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

56-66

Kód UT WoS článku

000459839600006

EID výsledku v databázi Scopus

2-s2.0-85057147601