Inappropriate conversion of current magnitude to current density may misinterpret results

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108532" target="_blank" >RIV/00216224:14110/19:00108532 - isvavai.cz</a>
Výsledek na webu
<a href="https://esc365.escardio.org/Congress/EHRA-2019/Poster-session-2-43rd-EWGCCE-Meeting/190047-inappropriate-conversion-of-current-magnitude-to-current-density-may-misinterpret-results#abstract" target="_blank" >https://esc365.escardio.org/Congress/EHRA-2019/Poster-session-2-43rd-EWGCCE-Meeting/190047-inappropriate-conversion-of-current-magnitude-to-current-density-may-misinterpret-results#abstract</a>
DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Inappropriate conversion of current magnitude to current density may misinterpret results
Popis výsledku v původním jazyce
The magnitude of ionic current (I, in pA) is usually assumed to increase proportionally to the membrane area roughly estimated by measurement of the membrane capacitance (C, in pF). Hence, to lower differences of data measured in cells with varying cell membrane areas, the current density (J, in pA/pF) is routinely calculated as I/C ratio. However, if the I-C correlation was weak and insignificant, the conversion to J would be inappropriate and, if performed, could considerably change the interpretation of results.
Název v anglickém jazyce
Inappropriate conversion of current magnitude to current density may misinterpret results
Popis výsledku anglicky
The magnitude of ionic current (I, in pA) is usually assumed to increase proportionally to the membrane area roughly estimated by measurement of the membrane capacitance (C, in pF). Hence, to lower differences of data measured in cells with varying cell membrane areas, the current density (J, in pA/pF) is routinely calculated as I/C ratio. However, if the I-C correlation was weak and insignificant, the conversion to J would be inappropriate and, if performed, could considerably change the interpretation of results.

Projekt
<a href="/cs/project/NV16-30571A" target="_blank" >NV16-30571A: Klinický význam a elektrofyziologické zhodnocení mutace c.926C>T genu KCNQ1 (p.T309I) jako možné „founder mutation“ syndromu dlouhého intervalu QT</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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