The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00108588" target="_blank" >RIV/00216224:14110/19:00108588 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/19:00071802 RIV/61989592:15110/19:73599487

Výsledek na webu

<a href="http://dx.doi.org/10.2478/acb-2019-0020" target="_blank" >http://dx.doi.org/10.2478/acb-2019-0020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/acb-2019-0020" target="_blank" >10.2478/acb-2019-0020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function

Popis výsledku v původním jazyce

Reproductive period in woman is characterized by cyclic changes of endometrium and its regeneration. The factors important for proper function of the endometrium are anatomical structure, hormonal control and signalling pathways on molecular-genetic level. New knowledge on uterine microbiome, mutual epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) of endometrial cells refine our conception of changes on cellular level, endometrial receptivity and possible causes of endometrial dysfunction. Substantial information on bacterial colonisation of endometrium were discovered by new diagnostic methods using analysis of ribosomal RNA in 16S subunit which are able to detect and exactly identify bacteria that are not detectable by classic cultivation methods. Endometrial microbiome prevents development of pathogenous microorganisms and modulates function of endometrial cells. It has been proven that stromal cells contribute to regeneration of not only the endometrial stroma, but also of the epithelium. Activity of ovarian steroids and other factors leads to EMT/MET, which ensures different functions of endometrium throughout the menstrual cycle and pregnancy. The endometrial microbiome and mutual transition of stromal and epithelial endometrial cells are necessary for physiological functions of uterine mucosa including implantation and development of an embryo. © 2019 Karel Crha, Pavel Ventruba, Jana Žáková, Michal Ješeta, Radovan Pilka, Jan Vodička, Igor Crha, published by Sciendo.

Název v anglickém jazyce

The role of uterine microbiome and epithelial-mesenchymal transition in endometrial function

Popis výsledku anglicky

Reproductive period in woman is characterized by cyclic changes of endometrium and its regeneration. The factors important for proper function of the endometrium are anatomical structure, hormonal control and signalling pathways on molecular-genetic level. New knowledge on uterine microbiome, mutual epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) of endometrial cells refine our conception of changes on cellular level, endometrial receptivity and possible causes of endometrial dysfunction. Substantial information on bacterial colonisation of endometrium were discovered by new diagnostic methods using analysis of ribosomal RNA in 16S subunit which are able to detect and exactly identify bacteria that are not detectable by classic cultivation methods. Endometrial microbiome prevents development of pathogenous microorganisms and modulates function of endometrial cells. It has been proven that stromal cells contribute to regeneration of not only the endometrial stroma, but also of the epithelium. Activity of ovarian steroids and other factors leads to EMT/MET, which ensures different functions of endometrium throughout the menstrual cycle and pregnancy. The endometrial microbiome and mutual transition of stromal and epithelial endometrial cells are necessary for physiological functions of uterine mucosa including implantation and development of an embryo. © 2019 Karel Crha, Pavel Ventruba, Jana Žáková, Michal Ješeta, Radovan Pilka, Jan Vodička, Igor Crha, published by Sciendo.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30214 - Obstetrics and gynaecology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medical Journal of Cell Biology

ISSN

2544-3577

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

6

Strana od-do

146-151

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85075164272