The prevalence and characteristics of epilepsy in patients with relapsing-remitting multiple sclerosis treated with disease-modifying therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00116322" target="_blank" >RIV/00216224:14110/20:00116322 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00073011

Výsledek na webu

<a href="https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2020-4-7/prevalence-a-charakteristika-epilepsie-u-pacientu-s-relabujici-remitujici-formou-roztrousene-sklerozy-lecenych-imunomodulacni-terapii-123472/download?hl=cs" target="_blank" >https://www.csnn.eu/casopisy/ceska-slovenska-neurologie/2020-4-7/prevalence-a-charakteristika-epilepsie-u-pacientu-s-relabujici-remitujici-formou-roztrousene-sklerozy-lecenych-imunomodulacni-terapii-123472/download?hl=cs</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.14735/amcsnn2020424" target="_blank" >10.14735/amcsnn2020424</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The prevalence and characteristics of epilepsy in patients with relapsing-remitting multiple sclerosis treated with disease-modifying therapy

Popis výsledku v původním jazyce

Aim: The aim was to identify and describe patients with relapsing-remitting MS (RRMS) treated with a disease-modifying therapy who had a history of unprovoked seizure or epilepsy and to investigate the impact of epilepsy on the course and prognosis of MS. Materials and methods: Patients with RRMS treated with a disease-modifying therapy at a large MS centre of the university hospital by January 1, 2019 were included in this study. The annual relapse rate and Expanded Disability Status Scale (EDSS) before and after the fi rst seizure were evaluated. Results: 17 patients (2.27%) with a history of unprovoked seizure or epilepsy were identifi ed within the cohort of RRMS patients (N = 750). Active epilepsy, defi ned as the use of antiepileptic drugs or incidence of seizures within the last 5 years, was disclosed in 13 (73%) of them. Three patients had developed epilepsy before the fi rst signs of MS. The mean annual relapse rates in patients with epilepsy before and after the fi rst seizure were 0.12 and 0.5 (P = 0.1), resp. No signifi cant diff erence was found in terms of EDSS worsening at 2 years before and after the fi rst seizure (0.55 vs. 0.7; P = 0.38). The attack semiology and/or electroencephalogram recordings indicated a focal onset of seizures in 8 out of 17 patients (47%). Conclusion: The frequency of unprovoked seizure or epilepsy among RRMS patients in our cohort was 2.27%.

Název v anglickém jazyce

The prevalence and characteristics of epilepsy in patients with relapsing-remitting multiple sclerosis treated with disease-modifying therapy

Popis výsledku anglicky

Aim: The aim was to identify and describe patients with relapsing-remitting MS (RRMS) treated with a disease-modifying therapy who had a history of unprovoked seizure or epilepsy and to investigate the impact of epilepsy on the course and prognosis of MS. Materials and methods: Patients with RRMS treated with a disease-modifying therapy at a large MS centre of the university hospital by January 1, 2019 were included in this study. The annual relapse rate and Expanded Disability Status Scale (EDSS) before and after the fi rst seizure were evaluated. Results: 17 patients (2.27%) with a history of unprovoked seizure or epilepsy were identifi ed within the cohort of RRMS patients (N = 750). Active epilepsy, defi ned as the use of antiepileptic drugs or incidence of seizures within the last 5 years, was disclosed in 13 (73%) of them. Three patients had developed epilepsy before the fi rst signs of MS. The mean annual relapse rates in patients with epilepsy before and after the fi rst seizure were 0.12 and 0.5 (P = 0.1), resp. No signifi cant diff erence was found in terms of EDSS worsening at 2 years before and after the fi rst seizure (0.55 vs. 0.7; P = 0.38). The attack semiology and/or electroencephalogram recordings indicated a focal onset of seizures in 8 out of 17 patients (47%). Conclusion: The frequency of unprovoked seizure or epilepsy among RRMS patients in our cohort was 2.27%.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ceska a slovenska neurologie a neurochirurgie

ISSN

1210-7859

e-ISSN

1802-4041

Svazek periodika

83

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

424-427

Kód UT WoS článku

000566715200014

EID výsledku v databázi Scopus

2-s2.0-85090097887