Mechanisms and incidence of torsades de pointes tachycardia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00118093" target="_blank" >RIV/00216224:14110/20:00118093 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00073372

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/B9780128177280000267" target="_blank" >https://www.sciencedirect.com/science/article/pii/B9780128177280000267</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-817728-0.00026-7" target="_blank" >10.1016/B978-0-12-817728-0.00026-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanisms and incidence of torsades de pointes tachycardia

Popis výsledku v původním jazyce

Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.

Název v anglickém jazyce

Mechanisms and incidence of torsades de pointes tachycardia

Popis výsledku anglicky

Torsades de pointes (TdP) is a specific polymorphic ventricular tachycardia related to specific condition – QT interval prolongation in majority of cases. Mechanisms of TdP initiation and perpetuation are still not fully understood and are discussed in detail in this article. TdP is initiated by early afterdepolarizations (EADs). The L-type Ca current (ICa,L) and the Na–Ca exchange current (INCX) are the major currents with potential to create EADs. Density and activity of these currents are influenced by sex hormones which may thus contribute to sex differences in the susceptibility to triggered activity. Female sex was confirmed as an independent risk factor for TdP. In patients with acquired atrioventricular block females developed TdP at QT intervals shorter than males. Thus, there must be other sex specific factors that increase the risk of arrhythmias. In other words, the effect of sex goes beyond the action potential duration. The incidence of TdP is difficult to estimate due to differences in the methodology of a particular study. Nevetheless, it is clearly higher in women.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Sex and Cardiac Electrophysiology: Differences in Cardiac Electrical Disorders Between Men and Women

ISBN

9780128177280

Počet stran výsledku

6

Strana od-do

303-308

Počet stran knihy

1032

Název nakladatele

Academic Press

Místo vydání

Neuveden

Kód UT WoS kapitoly

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