Analysis of ions and organic acids in saliva in diagnostics of gastroesophageal reflux disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00118623" target="_blank" >RIV/00216224:14110/20:00118623 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/65269705:_____/20:00073869

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Analysis of ions and organic acids in saliva in diagnostics of gastroesophageal reflux disease

Popis výsledku v původním jazyce

Introduction: Gastroesophageal reflux disease (GERD) is a disease caused by backflow of gastric contents into the esophagus due to the failure of physiological antireflux mechanisms and can lead to esophageal and extraesophageal symptomatology. At the current time, the gold standard in diagnostics of GERD is 24-hour multichannel intraluminal impedance and pH monitoring (MII-pH) that is invasive, time consuming and expensive diagnostic method with not clear relevance in diagnostics of extraesophageal reflux (EER) and there is a need for new faster, cheaper and more sensitive diagnostic method for detection of EER. New potential target in diagnostic of GERD is saliva. One of the saliva’s protective mechanism during a reflux episode is neutralization of gastric acid by various buffering systems. Bicarbonate and phosphate constitute major salivary buffering components. Since reflux episodes occur more frequently and have a longer duration in patients having GERD, our study investigates the hypothesis that bicarbonate and phosphate ions might be elevated in saliva.

Název v anglickém jazyce

Analysis of ions and organic acids in saliva in diagnostics of gastroesophageal reflux disease

Popis výsledku anglicky

Introduction: Gastroesophageal reflux disease (GERD) is a disease caused by backflow of gastric contents into the esophagus due to the failure of physiological antireflux mechanisms and can lead to esophageal and extraesophageal symptomatology. At the current time, the gold standard in diagnostics of GERD is 24-hour multichannel intraluminal impedance and pH monitoring (MII-pH) that is invasive, time consuming and expensive diagnostic method with not clear relevance in diagnostics of extraesophageal reflux (EER) and there is a need for new faster, cheaper and more sensitive diagnostic method for detection of EER. New potential target in diagnostic of GERD is saliva. One of the saliva’s protective mechanism during a reflux episode is neutralization of gastric acid by various buffering systems. Bicarbonate and phosphate constitute major salivary buffering components. Since reflux episodes occur more frequently and have a longer duration in patients having GERD, our study investigates the hypothesis that bicarbonate and phosphate ions might be elevated in saliva.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30219 - Gastroenterology and hepatology

Projekt

<a href="/cs/project/NV17-31945A" target="_blank" >NV17-31945A: Vývoj neinvazivní diagnostiky extraezofageálních projevů refluxní choroby jícnu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů