Social housing promotes cognitive function and reduces anxiety and depressive-like behaviours in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00128271" target="_blank" >RIV/00216224:14110/22:00128271 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16270/22:43880351

Výsledek na webu

<a href="https://actavet.vfu.cz/91/4/0391/" target="_blank" >https://actavet.vfu.cz/91/4/0391/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2754/avb202291040391" target="_blank" >10.2754/avb202291040391</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Social housing promotes cognitive function and reduces anxiety and depressive-like behaviours in rats

Popis výsledku v původním jazyce

The aim of the study was to assess the impact of social isolation of rats in the post-weaning period using behavioural tests aimed at assessing cognitive function, anxiety, and depressive -like behaviours. The monitoring was performed in male Wistar rats which were housed after weaning either individually (n = 8) or in pairs (n = 8) for 33 days. In the open field, rats kept in isolation reared less often (P &lt; 0.05) than pair-housed rats. In the elevated plus-maze test, pair-housed rats entered the open arm more frequently (P = 0.002) and stayed in the closed arm less often (P = 0.019) compared to rats housed in isolation. In the forced swim test, climbing was seen more frequently (P = 0.016) in pair-housed rats whereas immobility was more common (P = 0.006) in rats housed individually. In the novel object recognition test, the pair-housed rats preferred (P = 0.014) the novel object whereas there was no difference (P = 0.107) in time spent by exploring familiar and novel objects in rats housed in isolation. Furthermore, juvenile rats housed for 33 days in isolation showed higher (P = 0.003) body weight gain during the monitored period than rats housed for the same period in pairs. Our findings are important not only in terms of assessing the impact of rat housing on their mental and physical development but also in terms of the accurate interpretation of the results of other experiments where the rat is used as a model organism.

Název v anglickém jazyce

Social housing promotes cognitive function and reduces anxiety and depressive-like behaviours in rats

Popis výsledku anglicky

The aim of the study was to assess the impact of social isolation of rats in the post-weaning period using behavioural tests aimed at assessing cognitive function, anxiety, and depressive -like behaviours. The monitoring was performed in male Wistar rats which were housed after weaning either individually (n = 8) or in pairs (n = 8) for 33 days. In the open field, rats kept in isolation reared less often (P &lt; 0.05) than pair-housed rats. In the elevated plus-maze test, pair-housed rats entered the open arm more frequently (P = 0.002) and stayed in the closed arm less often (P = 0.019) compared to rats housed in isolation. In the forced swim test, climbing was seen more frequently (P = 0.016) in pair-housed rats whereas immobility was more common (P = 0.006) in rats housed individually. In the novel object recognition test, the pair-housed rats preferred (P = 0.014) the novel object whereas there was no difference (P = 0.107) in time spent by exploring familiar and novel objects in rats housed in isolation. Furthermore, juvenile rats housed for 33 days in isolation showed higher (P = 0.003) body weight gain during the monitored period than rats housed for the same period in pairs. Our findings are important not only in terms of assessing the impact of rat housing on their mental and physical development but also in terms of the accurate interpretation of the results of other experiments where the rat is used as a model organism.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30105 - Physiology (including cytology)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta veterinaria (Brno)

ISSN

0001-7213

e-ISSN

1801-7576

Svazek periodika

91

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

391-400

Kód UT WoS článku

000880783400010

EID výsledku v databázi Scopus

2-s2.0-85140409099