Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00128412" target="_blank" >RIV/00216224:14110/22:00128412 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16170/22:43880393 RIV/62157124:16270/22:43880393

Výsledek na webu

<a href="http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php" target="_blank" >http://vetmed.agriculturejournals.cz/artkey/vet-202211-0001_efficacy-and-safety-of-higher-oral-doses-of-azaperone-to-achieve-sedation-in-pigs.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/56/2022-VETMED" target="_blank" >10.17221/56/2022-VETMED</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

Popis výsledku v původním jazyce

The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets.

Název v anglickém jazyce

Efficacy and safety of higher oral doses of azaperone to achieve sedation in pigs

Popis výsledku anglicky

The aim of this study is to evaluate the possibility of achieving more effective and prolonged sedation in pigs by the oral administration of increased doses of azaperone and to evaluate its safety. This was performed through a prospective randomised and double blinded study. A total of 32 weaned piglets were divided into 4 groups (8 in each group). Group A was given 1 ml of saline orally and served as the control group. Group B received azaperone orally at a dose of 4 mg/kg b.w. Group C received azaperone orally at a dose of 8 mg/kg b.w. Group D was given azaperone orally at a dose of 12 mg/kg b.w. The response to the defined stimulus, movement level, degree of salivation, body temperature, respiratory frequency, blood plasma azaperone concentration and biochemical variables were included in the trial. We found that by increasing the dose of the orally administered azaperone, the onset of the sedation is faster, the end of the sedation starts later and the sedation time is longer. However, the use of higher doses of oral azaperone is not suitable for piglets because the doses negatively affect the respiratory rate, body temperature, some biochemical parameters and cause the immobility of the piglets.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

1805-9392

Svazek periodika

67

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

553-561

Kód UT WoS článku

000868736000001

EID výsledku v databázi Scopus

2-s2.0-85143307012