An Organotypic Assay to Study Epithelial-Fibroblast Interactions in Human Breast

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F22%3A00128718" target="_blank" >RIV/00216224:14110/22:00128718 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/protocol/10.1007/978-1-0716-2193-6_16" target="_blank" >https://link.springer.com/protocol/10.1007/978-1-0716-2193-6_16</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-1-0716-2193-6_16" target="_blank" >10.1007/978-1-0716-2193-6_16</a>

Jazyk výsledku

angličtina

Název v původním jazyce

An Organotypic Assay to Study Epithelial-Fibroblast Interactions in Human Breast

Popis výsledku v původním jazyce

Epithelial–stromal interactions play an essential role in regulation of mammary gland development, homeostasis, and tumorigenesis. Fibroblasts constitute a substantial proportion of mammary gland stromal cells in human breast and have been recognized for their paracrine signaling and extracellular matrix production and remodeling roles during normal breast development as well as in breast cancer. However, our current knowledge on human breast fibroblast functions is incomplete. Here we provide a detailed protocol for an organotypic human breast assay to facilitate research in the roles of human breast fibroblasts in mammary epithelial morphogenesis and early tumorigenesis.

Název v anglickém jazyce

An Organotypic Assay to Study Epithelial-Fibroblast Interactions in Human Breast

Popis výsledku anglicky

Epithelial–stromal interactions play an essential role in regulation of mammary gland development, homeostasis, and tumorigenesis. Fibroblasts constitute a substantial proportion of mammary gland stromal cells in human breast and have been recognized for their paracrine signaling and extracellular matrix production and remodeling roles during normal breast development as well as in breast cancer. However, our current knowledge on human breast fibroblast functions is incomplete. Here we provide a detailed protocol for an organotypic human breast assay to facilitate research in the roles of human breast fibroblasts in mammary epithelial morphogenesis and early tumorigenesis.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10601 - Cell biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Mammary Stem Cells

ISBN

9781071621929

Počet stran výsledku

17

Strana od-do

283-299

Počet stran knihy

354

Název nakladatele

Springer New York - Humana Press

Místo vydání

New York

Kód UT WoS kapitoly

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