Bilateral and multiple non-syndromic dentigerous cysts – are they that rare?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00133528" target="_blank" >RIV/00216224:14110/23:00133528 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijom.2023.10.458" target="_blank" >http://dx.doi.org/10.1016/j.ijom.2023.10.458</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijom.2023.10.458" target="_blank" >10.1016/j.ijom.2023.10.458</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Bilateral and multiple non-syndromic dentigerous cysts – are they that rare?

Popis výsledku v původním jazyce

Background: Dentigerous cysts (DCs) are the most common developmental odontogenic cysts (OCs) and the second most common cysts of the jaws. Bilateral and multiple DCs are usually associated with various syndromes, such as mucopolysaccharidoses or cleidocranial dysplasia; however, they are generally considered to be rare (1.8 – 3 %) in non-syndromic patients. Objectives: Here, we aimed to investigate the incidence of bilateral and multiple DCs in our cohort of patients with OCs. Methods: Patients with suspected OCs examined in 2022 at the University Hospital Brno and meeting all of the following criteria were included in the study: i) well-circumscribed translucency of the cyst associated with an impacted tooth on the OPG, ii) histopathological confirmation of OC. Patients with recurrent cysts were excluded from the study. Findings: In total, 48 patients with newly diagnosed developmental OCs were identified. 7 patients had an odontogenic keratocyst (mean age 37.8 years, 66.6% of men) and 41 patients met the criteria for DCs (mean age 43.9 years, 65.9 % of men); none of the DC patients suffered from a syndrome. Bilateral DCs adjacent to the lower wisdom teeth were presented in 2 patients, another patient had multiple DCs located around upper right wisdom tooth and the lower third molars. Our findings showed that 7.3 % of patients with a DC presented multiple DCs. Conclusion: While multiple DCs are rarer than sporadic single DCs, we suggest avoiding phrases such as “extremely rare” for describing the occurrence of multiple non-syndromic DCs. Compared to some other rare multiple developmental OCs such as the orthokeratinizing odontogenic cyst, multiple non-syndromic DCs are much more common.

Název v anglickém jazyce

Bilateral and multiple non-syndromic dentigerous cysts – are they that rare?

Popis výsledku anglicky

Background: Dentigerous cysts (DCs) are the most common developmental odontogenic cysts (OCs) and the second most common cysts of the jaws. Bilateral and multiple DCs are usually associated with various syndromes, such as mucopolysaccharidoses or cleidocranial dysplasia; however, they are generally considered to be rare (1.8 – 3 %) in non-syndromic patients. Objectives: Here, we aimed to investigate the incidence of bilateral and multiple DCs in our cohort of patients with OCs. Methods: Patients with suspected OCs examined in 2022 at the University Hospital Brno and meeting all of the following criteria were included in the study: i) well-circumscribed translucency of the cyst associated with an impacted tooth on the OPG, ii) histopathological confirmation of OC. Patients with recurrent cysts were excluded from the study. Findings: In total, 48 patients with newly diagnosed developmental OCs were identified. 7 patients had an odontogenic keratocyst (mean age 37.8 years, 66.6% of men) and 41 patients met the criteria for DCs (mean age 43.9 years, 65.9 % of men); none of the DC patients suffered from a syndrome. Bilateral DCs adjacent to the lower wisdom teeth were presented in 2 patients, another patient had multiple DCs located around upper right wisdom tooth and the lower third molars. Our findings showed that 7.3 % of patients with a DC presented multiple DCs. Conclusion: While multiple DCs are rarer than sporadic single DCs, we suggest avoiding phrases such as “extremely rare” for describing the occurrence of multiple non-syndromic DCs. Compared to some other rare multiple developmental OCs such as the orthokeratinizing odontogenic cyst, multiple non-syndromic DCs are much more common.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30101 - Human genetics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů