Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish<i> (Danio</i><i> rerio)?</i>

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00133660" target="_blank" >RIV/00216224:14110/23:00133660 - isvavai.cz</a>

Výsledek na webu

<a href="https://vetmed.agriculturejournals.cz/artkey/vet-202305-0005_long-term-exposure-to-polycyclic-musk-tonalide-8211-a-potential-threat-to-juvenile-zebrafish-danio-rerio.php" target="_blank" >https://vetmed.agriculturejournals.cz/artkey/vet-202305-0005_long-term-exposure-to-polycyclic-musk-tonalide-8211-a-potential-threat-to-juvenile-zebrafish-danio-rerio.php</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/40/2023-VETMED" target="_blank" >10.17221/40/2023-VETMED</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish<i> (Danio</i><i> rerio)?</i>

Popis výsledku v původním jazyce

Polycyclic musk compounds are commonly used in personal care products to replace expensive natural fragrances. Due to their huge consumption, they have become a part of the aquatic environment. In the present a two-month exposure effect of tonalide on juvenile zebrafish (Danio rerio) was investigated. We deter-mined the vitellogenin concentration to define the potential endocrine-disrupting effect of tonalide and also ana-selected indices to evaluate the induction of oxidative stress. The environmentally relevant concentration tonalide (i.e., 500 ng/l) caused a significant decrease in the catalase activity (P &lt; 0.05) and a significant increase 0.05) in the lipid peroxidation. An increasing lipid peroxidation was also recorded for the highest concentra-group tested (i.e., 50 000 ng/l). On the other hand, no significant changes were recorded in vitellogenin in all exposed groups. Thus, based on these results, we have not demonstrated the endocrine-disrupting activity tonalide in zebrafish. The results of the oxidative stress indices showed a significant impairment of the anti-oxidant defence after the two-month tonalide exposure, which could indicate part of the adaptive response tonalide toxicity.

Název v anglickém jazyce

Long-term exposure to polycyclic musk tonalide- A potential threat to juvenile zebrafish<i> (Danio</i><i> rerio)?</i>

Popis výsledku anglicky

Polycyclic musk compounds are commonly used in personal care products to replace expensive natural fragrances. Due to their huge consumption, they have become a part of the aquatic environment. In the present a two-month exposure effect of tonalide on juvenile zebrafish (Danio rerio) was investigated. We deter-mined the vitellogenin concentration to define the potential endocrine-disrupting effect of tonalide and also ana-selected indices to evaluate the induction of oxidative stress. The environmentally relevant concentration tonalide (i.e., 500 ng/l) caused a significant decrease in the catalase activity (P &lt; 0.05) and a significant increase 0.05) in the lipid peroxidation. An increasing lipid peroxidation was also recorded for the highest concentra-group tested (i.e., 50 000 ng/l). On the other hand, no significant changes were recorded in vitellogenin in all exposed groups. Thus, based on these results, we have not demonstrated the endocrine-disrupting activity tonalide in zebrafish. The results of the oxidative stress indices showed a significant impairment of the anti-oxidant defence after the two-month tonalide exposure, which could indicate part of the adaptive response tonalide toxicity.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40300 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

1805-9392

Svazek periodika

68

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

218-224

Kód UT WoS článku

001001809800005

EID výsledku v databázi Scopus

2-s2.0-85161971823