The associations of maternal liver and lipid biomarkers in pregnancy with gestational diabetes and adverse pregnancy outcomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00142184" target="_blank" >RIV/00216224:14110/25:00142184 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

The associations of maternal liver and lipid biomarkers in pregnancy with gestational diabetes and adverse pregnancy outcomes

Popis výsledku v původním jazyce

Background and aims: Some studies (incl. our pilot results, Bartakova et al, JCM, 2024) suggest that women with GDM have a higher prevalence of metabolic syndrome compared to healthy pregnant women. The liver – namely metabolic dysfunction-associated liver disease (MAFLD) - plays a central role in orchestrating metabolic changes associated with metabolic syndrome. The aim of this study was (i) to investigate differences in lipids and liver enzyme levels (LEL incl. ALP, ALT, ALP, GMT) between pregnant women with and without GDM, (ii) to examine the correlation of lipids and LEL during pregnancy with the risk of conversion of GDM to persistent pre-/diabetes after delivery and (iii) to find a possible correlation with adverse peripartal events. Materials and methods: The study included 109 healthy pregnant women and 163 GDM patients. In 77% birth data were available. Repeated oGTT after delivery underwent 42% (n = 68) GDM patients and in 13% (n = 9) the conversion to PGI was confirmed. Parameters: Age at the time of dg. GDM, pre-gestational BMI, lipid profile at dg. GDM (24-28th week) and just before delivery (±38th week), liver enzymes at the time of dg. GDM, glycemia during oGTT test, delivery data. Results: Patients with GDM had significantly lower values of total cholesterol (TC), LDL and HDL before delivery compared to controls (P=0.0004, 0.01 and 0.01 resp., Man Whitney test), in the 2nd trimester the parameters did not differ. Lipid values in the GDM group of PGI patients did not differ from the rest of the GDM patients. Pre- gestational BMI negatively correlated with HDL in all three samples, the fetal weight positively correlated with LDL and TC in the 2nd trimester. Patients with induced labour had significantly higher TAG and lower HDL values before birth, the HDL was lower in the 2nd trimester. With the exception of ALP (higher in GDM group, P=0.01, Man Whitney), no other differences between groups or correlations were found in LEL. Conclusion: Lipid spectrum values in patients with and without GDM did not differ significantly during the pregnancy. Patients with GDM had - hypothetically due to the effective dietary education - lower LDL and TC compared to healthy women before delivery. LEL were also similar in both groups, only ALP in GDM patient was higher during pregnancy, but it has no influence on peripartal outcomes or PGI conversion. Acknowledgement: The study was supported by the National Institute for Research of Metabolic and National Institute for research of Metabolic and Cardiovascular Disease project (Programme EXCELES, ID Project LX22NPO5104) funded by the Next Generation EU and AZV NW24-01-00285 from Ministry of Health Czech Rep.

Název v anglickém jazyce

The associations of maternal liver and lipid biomarkers in pregnancy with gestational diabetes and adverse pregnancy outcomes

Popis výsledku anglicky

Background and aims: Some studies (incl. our pilot results, Bartakova et al, JCM, 2024) suggest that women with GDM have a higher prevalence of metabolic syndrome compared to healthy pregnant women. The liver – namely metabolic dysfunction-associated liver disease (MAFLD) - plays a central role in orchestrating metabolic changes associated with metabolic syndrome. The aim of this study was (i) to investigate differences in lipids and liver enzyme levels (LEL incl. ALP, ALT, ALP, GMT) between pregnant women with and without GDM, (ii) to examine the correlation of lipids and LEL during pregnancy with the risk of conversion of GDM to persistent pre-/diabetes after delivery and (iii) to find a possible correlation with adverse peripartal events. Materials and methods: The study included 109 healthy pregnant women and 163 GDM patients. In 77% birth data were available. Repeated oGTT after delivery underwent 42% (n = 68) GDM patients and in 13% (n = 9) the conversion to PGI was confirmed. Parameters: Age at the time of dg. GDM, pre-gestational BMI, lipid profile at dg. GDM (24-28th week) and just before delivery (±38th week), liver enzymes at the time of dg. GDM, glycemia during oGTT test, delivery data. Results: Patients with GDM had significantly lower values of total cholesterol (TC), LDL and HDL before delivery compared to controls (P=0.0004, 0.01 and 0.01 resp., Man Whitney test), in the 2nd trimester the parameters did not differ. Lipid values in the GDM group of PGI patients did not differ from the rest of the GDM patients. Pre- gestational BMI negatively correlated with HDL in all three samples, the fetal weight positively correlated with LDL and TC in the 2nd trimester. Patients with induced labour had significantly higher TAG and lower HDL values before birth, the HDL was lower in the 2nd trimester. With the exception of ALP (higher in GDM group, P=0.01, Man Whitney), no other differences between groups or correlations were found in LEL. Conclusion: Lipid spectrum values in patients with and without GDM did not differ significantly during the pregnancy. Patients with GDM had - hypothetically due to the effective dietary education - lower LDL and TC compared to healthy women before delivery. LEL were also similar in both groups, only ALP in GDM patient was higher during pregnancy, but it has no influence on peripartal outcomes or PGI conversion. Acknowledgement: The study was supported by the National Institute for Research of Metabolic and National Institute for research of Metabolic and Cardiovascular Disease project (Programme EXCELES, ID Project LX22NPO5104) funded by the Next Generation EU and AZV NW24-01-00285 from Ministry of Health Czech Rep.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů