Mechanics and Mechanisms of Mouse Incisor Growth and Repair

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00144391" target="_blank" >RIV/00216224:14110/25:00144391 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/25:00144439

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Mechanics and Mechanisms of Mouse Incisor Growth and Repair

Popis výsledku v původním jazyce

Continuously growing mouse incisors, have for decades served as a model system for investigating the mechanisms of regeneration and studying the stem cell niche. It has been shown that the growth rate of these teeth does not always proceed at the same pace but can be accelerated following injury. However, the dynamics of growth acceleration, the mechanisms responsible for damage detection and the subsequent process of stem cell niche activation remains entirely unresolved. Here, we provide new insights into the dynamics of mouse incisor regeneration, both in healthy (non-damaged) tooth and after its injury. To quantify incisor growth, we have invented a new method (BEE-ST: Bones and tEEth Spatio-Temporal growth monitoring approach) that allows to monitor the growth and healing dynamics of any hard tissue on micrometre scale in both space and time. Subsequently, using an interdisciplinary approach involving mathematical modelling, single-cell RNA-sequencing, spatial transcriptomics and lineage tracing, we reveal new mechanisms responsible for the detection of injury and we provide new insights into the mechanical, cellular and molecular mechanisms responsible for the acceleration of tooth growth. Our research approaches the study of continuously growing teeth from a new interdisciplinary perspective. These results shed light on the large complexity of biological and mechanical processes standing behind the regulation of continuous tooth growth and suggest a new insight into stem cell niche activation from a more general perspective.

Název v anglickém jazyce

Mechanics and Mechanisms of Mouse Incisor Growth and Repair

Popis výsledku anglicky

Continuously growing mouse incisors, have for decades served as a model system for investigating the mechanisms of regeneration and studying the stem cell niche. It has been shown that the growth rate of these teeth does not always proceed at the same pace but can be accelerated following injury. However, the dynamics of growth acceleration, the mechanisms responsible for damage detection and the subsequent process of stem cell niche activation remains entirely unresolved. Here, we provide new insights into the dynamics of mouse incisor regeneration, both in healthy (non-damaged) tooth and after its injury. To quantify incisor growth, we have invented a new method (BEE-ST: Bones and tEEth Spatio-Temporal growth monitoring approach) that allows to monitor the growth and healing dynamics of any hard tissue on micrometre scale in both space and time. Subsequently, using an interdisciplinary approach involving mathematical modelling, single-cell RNA-sequencing, spatial transcriptomics and lineage tracing, we reveal new mechanisms responsible for the detection of injury and we provide new insights into the mechanical, cellular and molecular mechanisms responsible for the acceleration of tooth growth. Our research approaches the study of continuously growing teeth from a new interdisciplinary perspective. These results shed light on the large complexity of biological and mechanical processes standing behind the regulation of continuous tooth growth and suggest a new insight into stem cell niche activation from a more general perspective.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů