Teeth can heal: Uncovering the cellular basis of dental healing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00144442" target="_blank" >RIV/00216224:14110/25:00144442 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Teeth can heal: Uncovering the cellular basis of dental healing

Popis výsledku v původním jazyce

Teeth play a crucial role in species survival. Dental damage can lead to tooth loss and severely compromise the well-being, or even survival, of an organism. Thus, several mechanisms have evolved by which teeth can heal themselves and prolong their functionality and lifespan. These are known as tertiary dentinogenesis, the process of secreting a new form of dentin that protects the dental pulp and ultimately protects the tooth and the organism from infection. Two types of tertiary dentinogenesis are recognised: reactionary and reparative. Reactionary dentinogenesis is typically triggered by mild damage, such as increased tooth wear, while reparative dentinogenesis responds to more severe insults, like deep carious lesions. In this project, we aim to simulate three types of tooth damage: i) mild - increased wear, ii) deep - caries, and iii) periodontitis, with the aim to uncover mechanisms by which the tooth perceives its own damage, and how it responds to it on the cellular and molecular level. With the use of state-of-the-art methods and approaches, such as spatiotemporal monitoring of hard tissue growth (BEE-ST method), use of genetically modified mouse strains, and advanced 3D imaging methods, we characterise the detailed microstructure and growth dynamics of tertiary dentins. We believe our results will contribute to advances in regenerative dentistry.

Název v anglickém jazyce

Teeth can heal: Uncovering the cellular basis of dental healing

Popis výsledku anglicky

Teeth play a crucial role in species survival. Dental damage can lead to tooth loss and severely compromise the well-being, or even survival, of an organism. Thus, several mechanisms have evolved by which teeth can heal themselves and prolong their functionality and lifespan. These are known as tertiary dentinogenesis, the process of secreting a new form of dentin that protects the dental pulp and ultimately protects the tooth and the organism from infection. Two types of tertiary dentinogenesis are recognised: reactionary and reparative. Reactionary dentinogenesis is typically triggered by mild damage, such as increased tooth wear, while reparative dentinogenesis responds to more severe insults, like deep carious lesions. In this project, we aim to simulate three types of tooth damage: i) mild - increased wear, ii) deep - caries, and iii) periodontitis, with the aim to uncover mechanisms by which the tooth perceives its own damage, and how it responds to it on the cellular and molecular level. With the use of state-of-the-art methods and approaches, such as spatiotemporal monitoring of hard tissue growth (BEE-ST method), use of genetically modified mouse strains, and advanced 3D imaging methods, we characterise the detailed microstructure and growth dynamics of tertiary dentins. We believe our results will contribute to advances in regenerative dentistry.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10605 - Developmental biology

Projekt

<a href="/cs/project/GA25-18087S" target="_blank" >GA25-18087S: Buněčná podstata hojení zubu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů