Endobiliary percutaneous cryobiopsy in biliary obstruction – randomised study (BICRYOB)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F25%3A00144763" target="_blank" >RIV/00216224:14110/25:00144763 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00270-025-04245" target="_blank" >http://dx.doi.org/10.1007/s00270-025-04245</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00270-025-04245" target="_blank" >10.1007/s00270-025-04245</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Endobiliary percutaneous cryobiopsy in biliary obstruction – randomised study (BICRYOB)

Popis výsledku v původním jazyce

Purpose: To assess feasibility and technical outcome of endobiliary cryobiopsy compared to standard technique of endobiliary forceps biopsy in randomized study. Material and Methods: This prospective study included 28 patients with indeterminate biliary stenosis. 22 patients underwent percutaneous endoluminal forceps biopsy and endoluminal cryobiopsy under the fluoroscopy guidance in one session. The order of sample collection was randomized. The technical feasibility of cryobiopsy and the rate of serious complications were analyzed. Sensitivity in detecting malignancy, sample weight, total sample area, sample area without artifacts, and sample quality (five-point Likert scale) assessed by two certified pathologists were compared between both methods. Results: No CTCAE v.5 grade 3-4 complications were reported during or after the procedure, and cryobiopsy was technically feasible in all patients. A total of 232 samples were collected (112 forceps biopsy, 120 cryobiopsy). Cryobiopsy detected carcinoma in 15 of 17 patients (88%), compared to 11 of 17 (65%) with forceps biopsy. Cryobiopsy provided significantly larger total and artifact-free sample areas (median 2.66 vs 0.84 mm2 and 1.77 vs 0.18 mm2, respectively; p&lt;0.001), fewer non-evaluable samples (8% vs 40%; p&lt;0,001), and a significantly greater median weight (7.6 vs 3.6 mg; p&lt;0.001). Cryobiopsy samples demonstrated markedly superior quality assessments (median Likert scale value 4 vs 2, p&lt;0.001; Likert &gt; 2 in 83% vs 38%, p&lt;0.001). Conclusion: Cryobiopsy in the biliary tract appears to be a safe and feasible technique, allowing more representative histological samples to be obtained compared with forceps biopsy.

Název v anglickém jazyce

Endobiliary percutaneous cryobiopsy in biliary obstruction – randomised study (BICRYOB)

Popis výsledku anglicky

Purpose: To assess feasibility and technical outcome of endobiliary cryobiopsy compared to standard technique of endobiliary forceps biopsy in randomized study. Material and Methods: This prospective study included 28 patients with indeterminate biliary stenosis. 22 patients underwent percutaneous endoluminal forceps biopsy and endoluminal cryobiopsy under the fluoroscopy guidance in one session. The order of sample collection was randomized. The technical feasibility of cryobiopsy and the rate of serious complications were analyzed. Sensitivity in detecting malignancy, sample weight, total sample area, sample area without artifacts, and sample quality (five-point Likert scale) assessed by two certified pathologists were compared between both methods. Results: No CTCAE v.5 grade 3-4 complications were reported during or after the procedure, and cryobiopsy was technically feasible in all patients. A total of 232 samples were collected (112 forceps biopsy, 120 cryobiopsy). Cryobiopsy detected carcinoma in 15 of 17 patients (88%), compared to 11 of 17 (65%) with forceps biopsy. Cryobiopsy provided significantly larger total and artifact-free sample areas (median 2.66 vs 0.84 mm2 and 1.77 vs 0.18 mm2, respectively; p&lt;0.001), fewer non-evaluable samples (8% vs 40%; p&lt;0,001), and a significantly greater median weight (7.6 vs 3.6 mg; p&lt;0.001). Cryobiopsy samples demonstrated markedly superior quality assessments (median Likert scale value 4 vs 2, p&lt;0.001; Likert &gt; 2 in 83% vs 38%, p&lt;0.001). Conclusion: Cryobiopsy in the biliary tract appears to be a safe and feasible technique, allowing more representative histological samples to be obtained compared with forceps biopsy.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

<a href="/cs/project/NU21-08-00561" target="_blank" >NU21-08-00561: Využití ireverzibilní elektroporace a vysokofrekvenční ireverzibilní elektroporace k léčbě okluzí metalických stentů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů