THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F94%3A00035805" target="_blank" >RIV/00216224:14110/94:00035805 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
Popis výsledku v původním jazyce
A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cellsto tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results.
Název v anglickém jazyce
THE COSTIMULATORY SIGNAL CD28 IS FULLY FUNCTIONAL BUT CANNOT CORRECT THE IMPAIRED ANTIGEN RESPONSE IN T-CELLS OF PATIENTS WITH COMMON VARIABLE IMMUNODEFICIENCY
Popis výsledku anglicky
A wide spectrum of different immunologic abnormalities have been postulated as being responsible for the impairment of specific antibody production and the decrease in all or selected immunoglobulin isotypes present in common variable immunodeficiency (CVID). These abnormalities include impaired B cell differentiation and/or function, defective macrophage function, and significant T cell defects. The aim of the present study was to delineate whether the accessory molecule CD28 is involved in the impaired antigen response of T cells from patients with CVID. Our results demonstrate that CD28 costimulation was functional in T cells stimulated with anti-CD3 or anti-TCR MoAb, but could not correct the impaired response of patients' peripheral blood T cellsto tetanus toroid. Analysis of patients' long-term cultured T cells further confirmed these results.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
1994
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
ISSN
0009-9104
e-ISSN
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Svazek periodika
95
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
6
Strana od-do
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Kód UT WoS článku
A1994MU82700003
EID výsledku v databázi Scopus
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