Stabilized antioxidative plant extracts formulated by liquisolid technique
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F20%3A00118250" target="_blank" >RIV/00216224:14160/20:00118250 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S1773224720313113" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224720313113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jddst.2020.102022" target="_blank" >10.1016/j.jddst.2020.102022</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Stabilized antioxidative plant extracts formulated by liquisolid technique
Popis výsledku v původním jazyce
Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.
Název v anglickém jazyce
Stabilized antioxidative plant extracts formulated by liquisolid technique
Popis výsledku anglicky
Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
ISSN
1773-2247
e-ISSN
2588-8943
Svazek periodika
60
Číslo periodika v rámci svazku
102022
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
13
Strana od-do
1-13
Kód UT WoS článku
000601051800002
EID výsledku v databázi Scopus
2-s2.0-85090554839