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Stabilized antioxidative plant extracts formulated by liquisolid technique

Identifikátory výsledku

  • Kód výsledku v IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F20%3A00118250" target="_blank" >RIV/00216224:14160/20:00118250 - isvavai.cz</a>

  • Výsledek na webu

    <a href="https://www.sciencedirect.com/science/article/pii/S1773224720313113" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224720313113</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.jddst.2020.102022" target="_blank" >10.1016/j.jddst.2020.102022</a>

Alternativní jazyky

  • Jazyk výsledku

    angličtina

  • Název v původním jazyce

    Stabilized antioxidative plant extracts formulated by liquisolid technique

  • Popis výsledku v původním jazyce

    Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.

  • Název v anglickém jazyce

    Stabilized antioxidative plant extracts formulated by liquisolid technique

  • Popis výsledku anglicky

    Plant extracts with antioxidant activity are an important source of natural drugs. Usually are used as liquids, which are voluminous and often unstable. To overcome these obstacles, fast disintegrating tablets with high content of antioxidants were prepared by an innovative way of dried liquisolid system. The thickened extracts of Aronia melanocarpa, Crataegus leavigata and Rosa canina (Rosaceae) were diluted with ethanol (E) or water (W) and adsorbed onto a porous aluminometasilicate magnesium carrier (Neusilin (R) US2). The resulting wet blends were coated with colloidal silica, mixed with filler, disintegrant, lubricant and compressed. Tablets with incorporated liquid extract were dried by two different techniques: microwave drying (MW) and hot air drying (HA) at two different times. Blends and tablets were evaluated for physical properties and their antioxidant activity (AA) was measured in a modified dissolution by ferric reducing antioxidant power assay (FRAP). Partial least squares method (PLS) and ANOVA were used to assess tablet properties depending on the composition and parameters of the product. A longer drying time increased the hardness and density but reduced the porosity and loss of drying of the tablets. Maximum hardness was achieved by combining E with HA. Overall, drying process and the use of water solvent showed slightly negatively effect on AA of tablets, which is mainly influenced by the type of used extract.

Klasifikace

  • Druh

    J<sub>imp</sub> - Článek v periodiku v databázi Web of Science

  • CEP obor

  • OECD FORD obor

    30104 - Pharmacology and pharmacy

Návaznosti výsledku

  • Projekt

  • Návaznosti

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Ostatní

  • Rok uplatnění

    2020

  • Kód důvěrnosti údajů

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Údaje specifické pro druh výsledku

  • Název periodika

    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

  • ISSN

    1773-2247

  • e-ISSN

    2588-8943

  • Svazek periodika

    60

  • Číslo periodika v rámci svazku

    102022

  • Stát vydavatele periodika

    NL - Nizozemsko

  • Počet stran výsledku

    13

  • Strana od-do

    1-13

  • Kód UT WoS článku

    000601051800002

  • EID výsledku v databázi Scopus

    2-s2.0-85090554839