Natural compounds with dual antimicrobial and anti-inflammatory effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F20%3A00118254" target="_blank" >RIV/00216224:14160/20:00118254 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s11101-020-09694-5" target="_blank" >https://link.springer.com/article/10.1007/s11101-020-09694-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s11101-020-09694-5" target="_blank" >10.1007/s11101-020-09694-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Natural compounds with dual antimicrobial and anti-inflammatory effects

Popis výsledku v původním jazyce

Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory activity. The review contains also the information about structure-activity relationships with respect to natural or semisynthetic origin of compounds and synergy effects between natural dual inhibitors and commercially available antibiotics. Data published from 2000 to 2018 were obtained using databases Google Scholar, Science Direct and Web of Science, and searching keywords such asalkaloids,anti-inflammatory activity, antimicrobial activity, chalcones, coumarins, flavonoids, IC50, lignans, MIC, natural compounds,synergistic effectandterpenoids, alone or in a combination. The primary criteria for the selection of appropriate compounds were the MICs and IC(50)s used for a quantification of effects. The natural compounds with activity close to the reference substances or showing MIC up to 32 mu g ml(-1), and IC(50)of anti-inflammatory effect up to 15 mu M were considered as promising. When available, information about in vivo testing was included. Reviewed dual inhibitors can represent modern therapeutic approach, especially when the process of inflammation is followed by a secondary bacterial infection. Benefits of dual inhibitors are based on better compliance of patients, decreased number of side effects and extended spectrum of action. [GRAPHICS] .

Název v anglickém jazyce

Natural compounds with dual antimicrobial and anti-inflammatory effects

Popis výsledku anglicky

Increasing antimicrobial resistance, together with the occurrence of side effects of NSAIDs or glucocorticoids represents certain motivation to search for new natural dual antimicrobial and anti-inflammatory drugs. We here present selected natural compounds, possessing both antimicrobial and anti-inflammatory activity. The review contains also the information about structure-activity relationships with respect to natural or semisynthetic origin of compounds and synergy effects between natural dual inhibitors and commercially available antibiotics. Data published from 2000 to 2018 were obtained using databases Google Scholar, Science Direct and Web of Science, and searching keywords such asalkaloids,anti-inflammatory activity, antimicrobial activity, chalcones, coumarins, flavonoids, IC50, lignans, MIC, natural compounds,synergistic effectandterpenoids, alone or in a combination. The primary criteria for the selection of appropriate compounds were the MICs and IC(50)s used for a quantification of effects. The natural compounds with activity close to the reference substances or showing MIC up to 32 mu g ml(-1), and IC(50)of anti-inflammatory effect up to 15 mu M were considered as promising. When available, information about in vivo testing was included. Reviewed dual inhibitors can represent modern therapeutic approach, especially when the process of inflammation is followed by a secondary bacterial infection. Benefits of dual inhibitors are based on better compliance of patients, decreased number of side effects and extended spectrum of action. [GRAPHICS] .

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytochemistry reviews

ISSN

1568-7767

e-ISSN

1572-980X

Svazek periodika

19

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

32

Strana od-do

1471-1502

Kód UT WoS článku

000543051200001

EID výsledku v databázi Scopus

2-s2.0-85086863550