Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00123167" target="_blank" >RIV/00216224:14160/21:00123167 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.scopus.com/record/display.uri?eid=2-s2.0-85112203308&origin=resultslist&sort=plf-f&src=s&st1=10.1080%2f13651501.2021.1962357&sid=f03bd77f6a040ba376eeade2bc9d5032&sot=b&sdt=b&sl=34&s=DOI%2810.1080%2f13651501.2021.1962357%29&relpos=0&citeCnt=0&" target="_blank" >https://www.scopus.com/record/display.uri?eid=2-s2.0-85112203308&origin=resultslist&sort=plf-f&src=s&st1=10.1080%2f13651501.2021.1962357&sid=f03bd77f6a040ba376eeade2bc9d5032&sot=b&sdt=b&sl=34&s=DOI%2810.1080%2f13651501.2021.1962357%29&relpos=0&citeCnt=0&</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/13651501.2021.1962357" target="_blank" >10.1080/13651501.2021.1962357</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study

Popis výsledku v původním jazyce

Objective Patients with schizophrenia are at higher risk of cardiovascular (CVS) related mortality. Close attention is being paid to the clinical utility of readily available CVS markers. Methods A pilot one-year longitudinal study in inpatients with first-episode psychosis (FEP) was carried out to determine markers of inflammation and endothelial dysfunction (monocyte- and neutrophil-to-lymphocyte ratios) and basal blood pressure, pulse, and derived hemodynamic parameters (PP: pulse pressure; RPP: rate pressure product; and MAP: mean arterial pressure). Results After one year, PP and RPP increased, as did systolic blood pressure and heart rate. Systolic blood pressure, PP, total white blood cells, and neutrophils correlated with weight gain. After one year, correlations between monocyte-to-lymphocyte ratio and RPP and MAP were observed. Conclusion Our study indicates worsening CVS health over the first year of treatment and emphasises the importance of early monitoring of CVS status using easily accessible parameters to prevent CVS-related mortality.

Název v anglickém jazyce

Hemodynamic and white blood cells parameters in patients with first-episode psychosis: a pilot longitudinal study

Popis výsledku anglicky

Objective Patients with schizophrenia are at higher risk of cardiovascular (CVS) related mortality. Close attention is being paid to the clinical utility of readily available CVS markers. Methods A pilot one-year longitudinal study in inpatients with first-episode psychosis (FEP) was carried out to determine markers of inflammation and endothelial dysfunction (monocyte- and neutrophil-to-lymphocyte ratios) and basal blood pressure, pulse, and derived hemodynamic parameters (PP: pulse pressure; RPP: rate pressure product; and MAP: mean arterial pressure). Results After one year, PP and RPP increased, as did systolic blood pressure and heart rate. Systolic blood pressure, PP, total white blood cells, and neutrophils correlated with weight gain. After one year, correlations between monocyte-to-lymphocyte ratio and RPP and MAP were observed. Conclusion Our study indicates worsening CVS health over the first year of treatment and emphasises the importance of early monitoring of CVS status using easily accessible parameters to prevent CVS-related mortality.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Psychiatry in Clinical Practice

ISSN

1365-1501

e-ISSN

1471-1788

Svazek periodika

Neuveden.

Číslo periodika v rámci svazku

August

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

4

Strana od-do

1-4

Kód UT WoS článku

000683657200001

EID výsledku v databázi Scopus

2-s2.0-85112203308