Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates

Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F21%3A00123238" target="_blank" >RIV/00216224:14160/21:00123238 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Jazyk výsledku
angličtina
Název v původním jazyce
Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates
Popis výsledku v původním jazyce
Histone deacetylases (HDACs) have been long linked with tumor progression, demonstrating their important role in neoplasia. Inhibitors of HDAC (HDACI), which form a complex with Zn2+ ions in the active site of enzymes, are novel anticancer agents that induce tumor cell death, differentiation, and/or cell cycle arrest. We have designed and synthesized a series of N-hydroxycinnamamide derivates based on common HDAC`s pharmacophore with diversely substituted anilides.
Název v anglickém jazyce
Synthesis and antiproliferative activity of selected N-hydroxycinnamamide derivates
Popis výsledku anglicky
Histone deacetylases (HDACs) have been long linked with tumor progression, demonstrating their important role in neoplasia. Inhibitors of HDAC (HDACI), which form a complex with Zn2+ ions in the active site of enzymes, are novel anticancer agents that induce tumor cell death, differentiation, and/or cell cycle arrest. We have designed and synthesized a series of N-hydroxycinnamamide derivates based on common HDAC`s pharmacophore with diversely substituted anilides.

Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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