Práškové částice pro plicní podání

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00125336" target="_blank" >RIV/00216224:14160/22:00125336 - isvavai.cz</a>

Výsledek na webu

<a href="http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3985/3896" target="_blank" >http://chemicke-listy.cz/ojs3/index.php/chemicke-listy/article/view/3985/3896</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.54779/chl20220028" target="_blank" >10.54779/chl20220028</a>

Jazyk výsledku

čeština

Název v původním jazyce

Práškové částice pro plicní podání

Popis výsledku v původním jazyce

The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.

Název v anglickém jazyce

Dry Powder Particles for Pulmonary Application

Popis výsledku anglicky

The deposition of a drug to its required destination is crucial for effective lung treatment. It is important to design a suitable formulation that delivers the active ingredient to the desired site and resists the natural cleansing mechanisms of the airways. Large porous particles used as active substance carriers appear to be the most effective option for lung drug delivery. The present article provides a basic overview of the mechanisms of deposition of dry inhalable powders and methods of their preparation and evaluation. Spray drying together with micronization and crystallization techniques are among the most used methods of preparation of the discussed particles. Besides, these techniques can be combined with other production processes (encapsulation, emulsification, etc.). The evaluation of the properties of particles suitable for pulmonary application is based on specific requirements for their density, porosity, shape, aerodynamic parameters, and deposition in the lungs, which can now be simulated on an accurate model of artificial lungs.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CHEMICKÉ LISTY

ISSN

0009-2770

e-ISSN

—

Svazek periodika

116

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

28-34

Kód UT WoS článku

000744052500001

EID výsledku v databázi Scopus

2-s2.0-85122991189