Study of Biological Activity of Novel Hydroxamic Acids Derived From Vorinostat as the Inhibitor of Histone Deacetylases
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126408" target="_blank" >RIV/00216224:14160/22:00126408 - isvavai.cz</a>
Výsledek na webu
<a href="https://sciendo.com/issue/afpuc/69/s1" target="_blank" >https://sciendo.com/issue/afpuc/69/s1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/afpuc-2022-0009" target="_blank" >10.2478/afpuc-2022-0009</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Study of Biological Activity of Novel Hydroxamic Acids Derived From Vorinostat as the Inhibitor of Histone Deacetylases
Popis výsledku v původním jazyce
Histone deacetylase inhibitors (iHDACs), a class of epigenetic regulators, are substances with anticancer activity that is associated with inhibition of cell proliferation, induction of programmed cell death, inhibition of angiogenesis, and induction of the cytodifferentiation process in cancer cells. Hydroxamic acid derivatives are currently the most important group of iHDACs. Our study was focused on the evaluation of biological activity of new hydroxamic acids derivates as potential iHDACs designed and synthesised by the Department of Chemical Drugs in Faculty of Pharmacy at Masaryk University.
Název v anglickém jazyce
Study of Biological Activity of Novel Hydroxamic Acids Derived From Vorinostat as the Inhibitor of Histone Deacetylases
Popis výsledku anglicky
Histone deacetylase inhibitors (iHDACs), a class of epigenetic regulators, are substances with anticancer activity that is associated with inhibition of cell proliferation, induction of programmed cell death, inhibition of angiogenesis, and induction of the cytodifferentiation process in cancer cells. Hydroxamic acid derivatives are currently the most important group of iHDACs. Our study was focused on the evaluation of biological activity of new hydroxamic acids derivates as potential iHDACs designed and synthesised by the Department of Chemical Drugs in Faculty of Pharmacy at Masaryk University.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2022
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů