NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126647" target="_blank" >RIV/00216224:14160/22:00126647 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

Popis výsledku v původním jazyce

Carbonic anhydrases (CA, EC 4.2.1.1) are metallo-enzymes present in various organisms. In pathogenic bacteria, CAs play an important role in growth and survival. Inhibition of bacterial CAs leads to growth defects, growth retardation and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs were synthesized as potential bacterial CAs inhibitors. Newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body.

Název v anglickém jazyce

NOVEL 1,3,5-TRIAZINYL AMINOBENZENESULFONAMIDES AS POTENT ANTI-VRE AGENTS, AND CARBONIC ANHYDRASES I, II, VII, IX, AND XII INHIBITORS

Popis výsledku anglicky

Carbonic anhydrases (CA, EC 4.2.1.1) are metallo-enzymes present in various organisms. In pathogenic bacteria, CAs play an important role in growth and survival. Inhibition of bacterial CAs leads to growth defects, growth retardation and makes bacterias vulnerable to host defense mechanisms. Bacterial CAs are therefore a very promising target in the search for new antibiotics. A series of 1,3,5-triazinyl aminobenzenesulfonamides substituted by aminoalcohol, aminostilbene, and aminochalcone structural motifs were synthesized as potential bacterial CAs inhibitors. Newly prepared compounds have a great potential as antibacterial agents with high activity and at the same time with high selectivity for bacterial CA in comparison with metabolically important hCA isoenzymes (e.g. hCA I, hCA II) found in the human body.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30107 - Medicinal chemistry

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Czech Chemical Society Symposium Series

ISBN

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ISSN

2336-7210

e-ISSN

2336-7210

Počet stran výsledku

2

Strana od-do

14-15

Název nakladatele

Czech Chemical Society

Místo vydání

Prague, Czech republic

Místo konání akce

Milovy, Czech Republic

Datum konání akce

1. 1. 2022

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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