Preparation and evaluation of spray-dried microparticles containing colistin or liposomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F22%3A00126882" target="_blank" >RIV/00216224:14160/22:00126882 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.pharm.muni.cz/veda-a-vyzkum/svk/doktorsti-studenti/archiv-sborniku/2022" target="_blank" >https://www.pharm.muni.cz/veda-a-vyzkum/svk/doktorsti-studenti/archiv-sborniku/2022</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and evaluation of spray-dried microparticles containing colistin or liposomes

Popis výsledku v původním jazyce

In this study, a formulation containing the antibacterial agent colistin for lung application was prepared using different input spray drying parameters (temperature, dispersion or ingredient concentration, nozzle size). In the second part, the incorporation of liposomes (as a potential carrier for colistin) into the microparticles and their stability after the drying process were evaluated. The results show the best properties with a high leucine concentration, dilution of input dispersion, and high drying temperature. Compositions used for liposome batches were not completely effective in stabilizing vesicles during spray drying. However, increasing the concentration of mannitol protectant shows promising results, and the findings obtained are of great importance for further optimization.

Název v anglickém jazyce

Preparation and evaluation of spray-dried microparticles containing colistin or liposomes

Popis výsledku anglicky

In this study, a formulation containing the antibacterial agent colistin for lung application was prepared using different input spray drying parameters (temperature, dispersion or ingredient concentration, nozzle size). In the second part, the incorporation of liposomes (as a potential carrier for colistin) into the microparticles and their stability after the drying process were evaluated. The results show the best properties with a high leucine concentration, dilution of input dispersion, and high drying temperature. Compositions used for liposome batches were not completely effective in stabilizing vesicles during spray drying. However, increasing the concentration of mannitol protectant shows promising results, and the findings obtained are of great importance for further optimization.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů