Non-linear regression analysis of in vitro dissolution data: Development of particulate systems containing thymol

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00134103" target="_blank" >RIV/00216224:14160/23:00134103 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Non-linear regression analysis of in vitro dissolution data: Development of particulate systems containing thymol

Popis výsledku v původním jazyce

The aim of this experimental study was to explore in vitro release behavior of thymol self-emulsifying biopolymeric particles. Non-linear regression analysis was used to elucidate the kinetics and mechanism of thymol release from different types of biopolymeric particles. The hardening medium used was found to affect the drug release process significantly. Sample S1 (hardening solutions CaCl2) showed release by first-order kinetics and mechanism corresponding to anomalous transport. Sample S2 (hardening solutions CaCl2:ZnCl2) exhibited release by zero-order kinetics and swelling-controlled release mechanism. Sample 3 (hardening solutions ZnCl2) is a superposition of multiple states in terms of release kinetics and mechanism corresponding with Super Case II transport.

Název v anglickém jazyce

Non-linear regression analysis of in vitro dissolution data: Development of particulate systems containing thymol

Popis výsledku anglicky

The aim of this experimental study was to explore in vitro release behavior of thymol self-emulsifying biopolymeric particles. Non-linear regression analysis was used to elucidate the kinetics and mechanism of thymol release from different types of biopolymeric particles. The hardening medium used was found to affect the drug release process significantly. Sample S1 (hardening solutions CaCl2) showed release by first-order kinetics and mechanism corresponding to anomalous transport. Sample S2 (hardening solutions CaCl2:ZnCl2) exhibited release by zero-order kinetics and swelling-controlled release mechanism. Sample 3 (hardening solutions ZnCl2) is a superposition of multiple states in terms of release kinetics and mechanism corresponding with Super Case II transport.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GA22-03187S" target="_blank" >GA22-03187S: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů