Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F23%3A00134513" target="_blank" >RIV/00216224:14160/23:00134513 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666658/pdf/VETMED-68-10-123089.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666658/pdf/VETMED-68-10-123089.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.17221/89/2023-VETMED" target="_blank" >10.17221/89/2023-VETMED</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics

Popis výsledku v původním jazyce

The clinical implications and efficacy of newly developed modified cellulose materials were evaluated in an acute wound animal model. In the current study, sixty male rats were divided into four groups. A full-thickness circular excision wound was created in the suprascapular area. Newly developed matrices (acidic partially carboxymethylated cellulose; acidic partially carboxymethylated cellulose impregnated with a povidone-io dine solution) were applied in two test groups, while fifteen animals were used as a control group without any primary dressing. Aquacel Ag, a clinically used dressing, was selected as the reference material. To compare the efficacy in vivo, the wound size and production of selected cytokines and growth factors (TNF-alpha, TGF-131, and VEGF), which play a key role in the healing process, were measured at two, seven, and fourteen days after surgery. The activity of matrix metalloproteinases 2 and 9, which actively participate in cell signalling and are essential for tissue remodelling, was determined in wound tissue by gelatin zymography. A positive effect of the newly developed dressing materials on the healing process, tissue granulation, and wound re-epithelialisation was demonstrated.

Název v anglickém jazyce

Effect of novel carboxymethyl cellulose-based dressings on acute wound healing dynamics

Popis výsledku anglicky

The clinical implications and efficacy of newly developed modified cellulose materials were evaluated in an acute wound animal model. In the current study, sixty male rats were divided into four groups. A full-thickness circular excision wound was created in the suprascapular area. Newly developed matrices (acidic partially carboxymethylated cellulose; acidic partially carboxymethylated cellulose impregnated with a povidone-io dine solution) were applied in two test groups, while fifteen animals were used as a control group without any primary dressing. Aquacel Ag, a clinically used dressing, was selected as the reference material. To compare the efficacy in vivo, the wound size and production of selected cytokines and growth factors (TNF-alpha, TGF-131, and VEGF), which play a key role in the healing process, were measured at two, seven, and fourteen days after surgery. The activity of matrix metalloproteinases 2 and 9, which actively participate in cell signalling and are essential for tissue remodelling, was determined in wound tissue by gelatin zymography. A positive effect of the newly developed dressing materials on the healing process, tissue granulation, and wound re-epithelialisation was demonstrated.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/TH04020540" target="_blank" >TH04020540: Nová bioaktivní hemostatika a krytí ran na bázi kolagenu a celulózy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Veterinarni Medicina

ISSN

0375-8427

e-ISSN

1805-9392

Svazek periodika

68

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

403-411

Kód UT WoS článku

001098482400003

EID výsledku v databázi Scopus

2-s2.0-85178299083