Significance of flavonoids targeting PI3K/Akt/HIF-1a signaling pathway in therapy-resistant cancer cells - A potential contribution to the predictive, preventive, and personalized medicine

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F24%3A00139008" target="_blank" >RIV/00216224:14160/24:00139008 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60460709:41330/24:101618

Výsledek na webu

<a href="https://pdf.sciencedirectassets.com/279952/1-s2.0-S2090123223X00149/1-s2.0-S2090123223000668/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEN7%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIAxfvcE3n%2FMXEBIZNhxPJO9N0qbH1Lv%2F9ytPPnv0l774AiEAhh1tecl" target="_blank" >https://pdf.sciencedirectassets.com/279952/1-s2.0-S2090123223X00149/1-s2.0-S2090123223000668/main.pdf?X-Amz-Security-Token=IQoJb3JpZ2luX2VjEN7%2F%2F%2F%2F%2F%2F%2F%2F%2F%2FwEaCXVzLWVhc3QtMSJHMEUCIAxfvcE3n%2FMXEBIZNhxPJO9N0qbH1Lv%2F9ytPPnv0l774AiEAhh1tecl</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jare.2023.02.015" target="_blank" >10.1016/j.jare.2023.02.015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Significance of flavonoids targeting PI3K/Akt/HIF-1a signaling pathway in therapy-resistant cancer cells - A potential contribution to the predictive, preventive, and personalized medicine

Popis výsledku v původním jazyce

Background: Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically to maintain their supply of energy and precursor molecules for biosynthesis and thus sustain rapid proliferation and tumor growth. Among the various metabolic adaptations observed in cancer cells, the altered glucose metabolism is the most widely studied. The aberrant glycolytic modification in cancer cells has been associated with rapid cell division, tumor growth, cancer progression, and drug resistance. The higher rates of glycolysis in cancer cells, as a hallmark of cancer progression, is modulated by the transcription factor hypoxia inducible factor 1 alpha (HIF-1a), a downstream target of the PI3K/Akt signaling, the most deregulated pathway in cancer.Aim of Review: We provide a detailed overview of current, primarily experimental, evidence on the potential effectiveness of flavonoids to combat aberrant glycolysis-induced resistance of cancer cells to conventional and targeted therapies. The manuscript focuses primarily on flavonoids reducing cancer resistance via affecting PI3K/Akt, HIF-1a (as the transcription factor critical for glucose metabolism of cancer cells that is regulated by PI3K/Akt pathway), and key glycolytic mediators downstream of PI3K/Akt/HIF-1a signaling (glucose transporters and key glycolytic enzymes). Key ScientificConcepts of Review: The working hypothesis of the manuscript proposes HIF-1a - the transcription factor critical for glucose metabolism of cancer cells regulated by PI3K/Akt pathway as an attractive target for application of flavonoids to mitigate cancer resistance. Phytochemicals represent a source of promising substances for cancer management applicable to primary, secondary, and tertiary care. However, accurate patient stratification and individualized patient profiling represent crucial steps in the paradigm shift from reactive to predictive, preventive, and personalized medicine (PPPM / 3PM). The article is focused on targeting molecular patterns by natural substances and provides evidence based recommendations for the 3PM relevant implementation.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Název v anglickém jazyce

Significance of flavonoids targeting PI3K/Akt/HIF-1a signaling pathway in therapy-resistant cancer cells - A potential contribution to the predictive, preventive, and personalized medicine

Popis výsledku anglicky

Background: Cancer management faces multiple obstacles, including resistance to current therapeutic approaches. In the face of challenging microenvironments, cancer cells adapt metabolically to maintain their supply of energy and precursor molecules for biosynthesis and thus sustain rapid proliferation and tumor growth. Among the various metabolic adaptations observed in cancer cells, the altered glucose metabolism is the most widely studied. The aberrant glycolytic modification in cancer cells has been associated with rapid cell division, tumor growth, cancer progression, and drug resistance. The higher rates of glycolysis in cancer cells, as a hallmark of cancer progression, is modulated by the transcription factor hypoxia inducible factor 1 alpha (HIF-1a), a downstream target of the PI3K/Akt signaling, the most deregulated pathway in cancer.Aim of Review: We provide a detailed overview of current, primarily experimental, evidence on the potential effectiveness of flavonoids to combat aberrant glycolysis-induced resistance of cancer cells to conventional and targeted therapies. The manuscript focuses primarily on flavonoids reducing cancer resistance via affecting PI3K/Akt, HIF-1a (as the transcription factor critical for glucose metabolism of cancer cells that is regulated by PI3K/Akt pathway), and key glycolytic mediators downstream of PI3K/Akt/HIF-1a signaling (glucose transporters and key glycolytic enzymes). Key ScientificConcepts of Review: The working hypothesis of the manuscript proposes HIF-1a - the transcription factor critical for glucose metabolism of cancer cells regulated by PI3K/Akt pathway as an attractive target for application of flavonoids to mitigate cancer resistance. Phytochemicals represent a source of promising substances for cancer management applicable to primary, secondary, and tertiary care. However, accurate patient stratification and individualized patient profiling represent crucial steps in the paradigm shift from reactive to predictive, preventive, and personalized medicine (PPPM / 3PM). The article is focused on targeting molecular patterns by natural substances and provides evidence based recommendations for the 3PM relevant implementation.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Advanced Research

ISSN

2090-1232

e-ISSN

2090-1224

Svazek periodika

55

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

16

Strana od-do

103-118

Kód UT WoS článku

001150282600001

EID výsledku v databázi Scopus

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