Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F24%3A00139404" target="_blank" >RIV/00216224:14160/24:00139404 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR

Popis výsledku v původním jazyce

Incorporation of lipophilic drugs into liquid self-emulsifying systems proves to be an effective strategy for augmenting their solubility and bioavailability. Presently, there is a significant focus on exploring the potential of solidifying these systems, e.g., the formulation of pellets through extrusion/spheronization. The broader utilization of self-emulsifying systems would greatly benefit from the modified release, e.g., enabling drug delivery to distal regions of the intestine for oral application. Regrettably, the scientific community has provided limited information on this topic. Although some information exists regarding challenges in coated self-emulsifying pellets, comprehensive investigations remain scarce. This experimental study aims to formulate self-emulsifying pellets coated with Eudragit® L for precise drug delivery to the small intestinal region and to provide a detailed analysis and explanation of the observed difficulties. In this experimental study, dissolution profiles after three months suggest that introducing a sub-layer and TEC reduction could be a solution for the modified release of self-emulsifying pellets.

Název v anglickém jazyce

Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR

Popis výsledku anglicky

Incorporation of lipophilic drugs into liquid self-emulsifying systems proves to be an effective strategy for augmenting their solubility and bioavailability. Presently, there is a significant focus on exploring the potential of solidifying these systems, e.g., the formulation of pellets through extrusion/spheronization. The broader utilization of self-emulsifying systems would greatly benefit from the modified release, e.g., enabling drug delivery to distal regions of the intestine for oral application. Regrettably, the scientific community has provided limited information on this topic. Although some information exists regarding challenges in coated self-emulsifying pellets, comprehensive investigations remain scarce. This experimental study aims to formulate self-emulsifying pellets coated with Eudragit® L for precise drug delivery to the small intestinal region and to provide a detailed analysis and explanation of the observed difficulties. In this experimental study, dissolution profiles after three months suggest that introducing a sub-layer and TEC reduction could be a solution for the modified release of self-emulsifying pellets.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

<a href="/cs/project/GA22-03187S" target="_blank" >GA22-03187S: Racionální design částicových polysacharidových systémů pro přívod léčiv s širokým spekterem biologické aktivity k terapii sliznic</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů