Geranylated Flavonoids from Paulownia tomentosa Suppress Cancer Cell Proliferation and Trigger Apoptosis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00141800" target="_blank" >RIV/00216224:14160/25:00141800 - isvavai.cz</a>
Výsledek na webu
<a href="https://fd2025.sk/assets_congress/fd2025_sk2025/docs/72-nd-czech-slovak-pharmacological-days_1.pdf" target="_blank" >https://fd2025.sk/assets_congress/fd2025_sk2025/docs/72-nd-czech-slovak-pharmacological-days_1.pdf</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Geranylated Flavonoids from Paulownia tomentosa Suppress Cancer Cell Proliferation and Trigger Apoptosis
Popis výsledku v původním jazyce
The presence of secondary metabolites in Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae), particularly geranylated flavonoids, has recently garnered significant attention in the search for new biologically active compounds. Although these naturally occurring substances are found in a limited number of plant families, they are noteworthy for their potential pharmacological properties. Recently, geranylated flavonoids have been extensively studied for their various biological activities, which include anti-inflammatory, antibacterial, antioxidant, and cytotoxic effects. In this study, we showed that geranylated flavonoids from Paulownia tomentosa can effectively inhibit the growth of cancer cells, particularly the DU-145 prostate cancer cell line. The tested substances further induce apoptosis and changes in the mitochondrial activity of cancer cells.
Název v anglickém jazyce
Geranylated Flavonoids from Paulownia tomentosa Suppress Cancer Cell Proliferation and Trigger Apoptosis
Popis výsledku anglicky
The presence of secondary metabolites in Paulownia tomentosa (Thunb.) Steud. (Paulowniaceae), particularly geranylated flavonoids, has recently garnered significant attention in the search for new biologically active compounds. Although these naturally occurring substances are found in a limited number of plant families, they are noteworthy for their potential pharmacological properties. Recently, geranylated flavonoids have been extensively studied for their various biological activities, which include anti-inflammatory, antibacterial, antioxidant, and cytotoxic effects. In this study, we showed that geranylated flavonoids from Paulownia tomentosa can effectively inhibit the growth of cancer cells, particularly the DU-145 prostate cancer cell line. The tested substances further induce apoptosis and changes in the mitochondrial activity of cancer cells.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
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OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů