Undescribed prenylated anthraquinones from Asperula sintenisii Asch. Ex Bornm. with cytotoxic activities

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00142527" target="_blank" >RIV/00216224:14160/25:00142527 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0367326X2500471X?pes=vor&utm_source=clarivate&getft_integrator=clarivate" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0367326X2500471X?pes=vor&utm_source=clarivate&getft_integrator=clarivate</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.fitote.2025.106845" target="_blank" >10.1016/j.fitote.2025.106845</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Undescribed prenylated anthraquinones from Asperula sintenisii Asch. Ex Bornm. with cytotoxic activities

Popis výsledku v původním jazyce

Two previously unreported anthraquinones, named sintenisiquinones A (1) and B (2), were isolated from the MeOH extract of Asperula sintenisii together with five iridoid glycosides, five flavonoids, as well as three phenolic acid derivatives. Their chemical structures were elucidated on the basis of extensive 1D (1H and 13C) and 2D (COSY, HSQC, and HMBC) NMR spectroscopy and HRESIMS. Compounds 1 and 2 represent rare type of anthraquinone derivatives bearing a prenyl group cyclized to dihydrofuran ring. The in vitro cytotoxic activities of selected compounds (1-3, 5, 7, 11, 12 and 15) were evaluated against SW480, DU145, MCF7, and A549 cancer cell lines as well as a healthy cell line, L929 by MTS assay. Compounds 1 and 2 displayed weak cytotoxicity compared to positive control, doxorubicin. This is the first phytochemical and bioactivity studies on A. sintenisii, an endemic species to T &amp; uuml;rkiye.

Název v anglickém jazyce

Undescribed prenylated anthraquinones from Asperula sintenisii Asch. Ex Bornm. with cytotoxic activities

Popis výsledku anglicky

Two previously unreported anthraquinones, named sintenisiquinones A (1) and B (2), were isolated from the MeOH extract of Asperula sintenisii together with five iridoid glycosides, five flavonoids, as well as three phenolic acid derivatives. Their chemical structures were elucidated on the basis of extensive 1D (1H and 13C) and 2D (COSY, HSQC, and HMBC) NMR spectroscopy and HRESIMS. Compounds 1 and 2 represent rare type of anthraquinone derivatives bearing a prenyl group cyclized to dihydrofuran ring. The in vitro cytotoxic activities of selected compounds (1-3, 5, 7, 11, 12 and 15) were evaluated against SW480, DU145, MCF7, and A549 cancer cell lines as well as a healthy cell line, L929 by MTS assay. Compounds 1 and 2 displayed weak cytotoxicity compared to positive control, doxorubicin. This is the first phytochemical and bioactivity studies on A. sintenisii, an endemic species to T &amp; uuml;rkiye.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fitoterapia

ISSN

0367-326X

e-ISSN

1873-6971

Svazek periodika

186

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

001595290500002

EID výsledku v databázi Scopus

2-s2.0-105013873518