ANXIOLYTICS AS ACTIVE CONTAMINANTS IN AQUATIC ENVIRONMENTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F25%3A00143974" target="_blank" >RIV/00216224:14160/25:00143974 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

ANXIOLYTICS AS ACTIVE CONTAMINANTS IN AQUATIC ENVIRONMENTS

Popis výsledku v původním jazyce

Pharmaceuticals, particularly anxiolytics from the benzodiazepine class, represent a specific group of so-called micropollutants with a high potential for sublethal and behavioural effects on aquatic organisms, even at the very low concentrations commonly detected in wastewater and surface waters. These compounds exhibit persistence during conventional municipal wastewater treatment and, due to their biological activity, may affect the neurophysiology and behaviour of non-target aquatic animals, especially fish. For example, oxazepam has been detected in European rivers at concentrations up to 61 ng/L. Long-term exposure to mixtures of benzodiazepines (temazepam, clobazam, oxazepam, temazepam) has also been shown to result in bioaccumulation in fish tissue and synergistic behavioural effects that cannot be predicted from single-compound exposure. A recent field study investigated the migration behaviour of 279 Atlantic salmon (Salmo salar) in the Dalälven River (Sweden), where fish were exposed to an environmentally relevant dose of the anxiolytic clobazam. The results showed that treated individuals migrated faster, exhibited reduced shoaling behaviour, and a greater proportion reached the sea. However, these behavioural changes increased predation risk and disrupted the normal migratory strategy. In this context, we conducted our own study investigating the prevalence of four benzodiazepines—diazepam and its active metabolites oxazepam, temazepam, and nordazepam—in the waters of two rivers flowing through the second largest city (Brno) in the Czech Republic. Our findings highlight the need for a revised approach to environmental risk assessment of pharmaceuticals, one that includes behavioural endpoints. The results also support the development of “green pharmacy” principles and technological innovation aimed at improving the removal of these compounds from wastewater.

Název v anglickém jazyce

ANXIOLYTICS AS ACTIVE CONTAMINANTS IN AQUATIC ENVIRONMENTS

Popis výsledku anglicky

Pharmaceuticals, particularly anxiolytics from the benzodiazepine class, represent a specific group of so-called micropollutants with a high potential for sublethal and behavioural effects on aquatic organisms, even at the very low concentrations commonly detected in wastewater and surface waters. These compounds exhibit persistence during conventional municipal wastewater treatment and, due to their biological activity, may affect the neurophysiology and behaviour of non-target aquatic animals, especially fish. For example, oxazepam has been detected in European rivers at concentrations up to 61 ng/L. Long-term exposure to mixtures of benzodiazepines (temazepam, clobazam, oxazepam, temazepam) has also been shown to result in bioaccumulation in fish tissue and synergistic behavioural effects that cannot be predicted from single-compound exposure. A recent field study investigated the migration behaviour of 279 Atlantic salmon (Salmo salar) in the Dalälven River (Sweden), where fish were exposed to an environmentally relevant dose of the anxiolytic clobazam. The results showed that treated individuals migrated faster, exhibited reduced shoaling behaviour, and a greater proportion reached the sea. However, these behavioural changes increased predation risk and disrupted the normal migratory strategy. In this context, we conducted our own study investigating the prevalence of four benzodiazepines—diazepam and its active metabolites oxazepam, temazepam, and nordazepam—in the waters of two rivers flowing through the second largest city (Brno) in the Czech Republic. Our findings highlight the need for a revised approach to environmental risk assessment of pharmaceuticals, one that includes behavioural endpoints. The results also support the development of “green pharmacy” principles and technological innovation aimed at improving the removal of these compounds from wastewater.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů