Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F03%3A00009627" target="_blank" >RIV/00216224:14310/03:00009627 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/03:00008745

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands

Popis výsledku v původním jazyce

Bifunctional chelating ligands (BFC) sequestering radiometal ions are used in radioimunotherapy and diagnosis. BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules, e.g. monoclonal antibodies, small peptides, hormones, sugars, etc. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Both properties are strongly influenced by degree of derivatization of macrocyclic skeleton and type of linker attached to biomolecule. In this contribution, the influence of structural variation of linker of BFC on kinetic properties was studied. Under experimental conditions (t = 25 oC, I = 0.1 M KCl, pH = 5.6-7.1, cY = 7*10-7 M, cL = 1.6*10-5 M), which are closed to conditions of 90Y radiolabelling in nuclear medicine, the empirical order in reactivity in respect to yttrium(III) was obtained: DO3AP > DO3APPrA > DOTA > DO3A > DO3APABn The results of complexation kinetics were compared with da

Název v anglickém jazyce

Comparative Study of Complexation and Dissociation Kinetics of Yttrium(III) with DOTA-like Macrocylic Ligands

Popis výsledku anglicky

Bifunctional chelating ligands (BFC) sequestering radiometal ions are used in radioimunotherapy and diagnosis. BFC contain metal coordination unit (e.g. macrocycle) attached to biologically active molecules, e.g. monoclonal antibodies, small peptides, hormones, sugars, etc. The complexes should exhibit high thermodynamic stability and, of course, kinetic inertness under physiological conditions. Both properties are strongly influenced by degree of derivatization of macrocyclic skeleton and type of linker attached to biomolecule. In this contribution, the influence of structural variation of linker of BFC on kinetic properties was studied. Under experimental conditions (t = 25 oC, I = 0.1 M KCl, pH = 5.6-7.1, cY = 7*10-7 M, cL = 1.6*10-5 M), which are closed to conditions of 90Y radiolabelling in nuclear medicine, the empirical order in reactivity in respect to yttrium(III) was obtained: DO3AP > DO3APPrA > DOTA > DO3A > DO3APABn The results of complexation kinetics were compared with da

Druh

D - Stať ve sborníku

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2003

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Book of Abstracts of 5-th International Conference on f-elements - ICFE5. Geneva, Switzerland, August 24-29, 2003

ISBN

—

ISSN

—

e-ISSN

—

Počet stran výsledku

1

Strana od-do

—

Název nakladatele

SYMPORG SA

Místo vydání

Geneve

Místo konání akce

—

Datum konání akce

—

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—