Tautomerni rovnovahy purinovych derivatu studovane pomoci nizkoteplotni NMR spektroskopie

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010134" target="_blank" >RIV/00216224:14310/04:00010134 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tautomeric Equilibria of Purine Derivatives Studied by Low-Temperature NMR Spectroscopy

Popis výsledku v původním jazyce

Due to the fast chemical exchange between the tautomers at laboratory temperature, in the NMR spectra we can often see only one set of signals, representing the weighted average of contributions of each tautomers. Measuring the NMR spectra at low-temperature enables us to separate the signals of tautomers due to the slowing down the chemical exchange process. The NMR signals were assigned to individual tautomers on the basis of heteronuclear 2D correlation spectra. The characteristic chemical shifts andcoupling constants were used for determining the proton position on purine skeleton. The NMR parameters were also calculated by quantum chemical calculations and correlated with the experimental data. Combination of these two methods helps us to understand better the dependence of tautomeric populations and electronic distribution on the substitution patterns.

Název v anglickém jazyce

Tautomeric Equilibria of Purine Derivatives Studied by Low-Temperature NMR Spectroscopy

Popis výsledku anglicky

Due to the fast chemical exchange between the tautomers at laboratory temperature, in the NMR spectra we can often see only one set of signals, representing the weighted average of contributions of each tautomers. Measuring the NMR spectra at low-temperature enables us to separate the signals of tautomers due to the slowing down the chemical exchange process. The NMR signals were assigned to individual tautomers on the basis of heteronuclear 2D correlation spectra. The characteristic chemical shifts andcoupling constants were used for determining the proton position on purine skeleton. The NMR parameters were also calculated by quantum chemical calculations and correlated with the experimental data. Combination of these two methods helps us to understand better the dependence of tautomeric populations and electronic distribution on the substitution patterns.

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A016" target="_blank" >LN00A016: BIOMOLEKULÁRNÍ CENTRUM</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

VII Synthetic Chemistry Meeting and XXVI Finnish NMR Symposium

ISBN

951-39-1846-7

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

85-85

Název nakladatele

Department of Chemistry, University of Jyväskylä

Místo vydání

Jyväskylä, Finland

Místo konání akce

Keuruu, Finland

Datum konání akce

8. 6. 2004

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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