MD simulace na LgtC

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010190" target="_blank" >RIV/00216224:14310/04:00010190 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Dynamics Simulations on Glycosyltrasferase LgtC

Popis výsledku v původním jazyce

glycosyltransferases catalyze the transfer of glycosyl moieties from a donor sugar to an acceptor. In most cases, the donor is a nucleoside phosphosugar and the acceptor a hydroxyl group of another sugar, a lipid, or another component of glycoconjugates.The catalytic mechanism of the glycosyltransferases, however, still remains a mystery. The glycosyltransferases are classified as either retaining or inverting, depending on the stereochemical outcome of the reaction catalyzed. The galactosyltransferaseLgtC from Neisseria meningitidis is a retaning glycosyltransferase catalyzing a key step in the biosynthesis of lipooligosaccharide structure by transferring alpha-D-galactose from UDP-galactose to a terminal lactose. The comprehension of the catalyticmechanism is an essential precondition to be able to design an effective inhibitor of this enzyme, and to find an effective drug against the bacterial pathogen in this way. We report here the first molecular dynamics simulations of LgtC i

Název v anglickém jazyce

Molecular Dynamics Simulations on Glycosyltrasferase LgtC

Popis výsledku anglicky

glycosyltransferases catalyze the transfer of glycosyl moieties from a donor sugar to an acceptor. In most cases, the donor is a nucleoside phosphosugar and the acceptor a hydroxyl group of another sugar, a lipid, or another component of glycoconjugates.The catalytic mechanism of the glycosyltransferases, however, still remains a mystery. The glycosyltransferases are classified as either retaining or inverting, depending on the stereochemical outcome of the reaction catalyzed. The galactosyltransferaseLgtC from Neisseria meningitidis is a retaning glycosyltransferase catalyzing a key step in the biosynthesis of lipooligosaccharide structure by transferring alpha-D-galactose from UDP-galactose to a terminal lactose. The comprehension of the catalyticmechanism is an essential precondition to be able to design an effective inhibitor of this enzyme, and to find an effective drug against the bacterial pathogen in this way. We report here the first molecular dynamics simulations of LgtC i

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/LN00A016" target="_blank" >LN00A016: BIOMOLEKULÁRNÍ CENTRUM</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Materials Structure in Chemistry

ISBN

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ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

52-52

Název nakladatele

Czech and Slovak Crystallographic Association

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

1. 1. 2004

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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