Studium cytosolické GST pomocí elektromigračních metod.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00010320" target="_blank" >RIV/00216224:14310/04:00010320 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Study of cytosolic glutathione s-tranferase activity with styrene oxide by electromigration methods

Popis výsledku v původním jazyce

Styrene-7,8-oxide is an industrial chemical used in the manufacture of epoxy resins; as an intermediate in the preparation of various agricultural chemicals, cosmetics and plastics; and in the processing of textile and fibres. SO is also the major cytochrome P450 metabolite of styrene, used in plastic and resin manufacture. As epoxide, SO is highly reactive and able to undergo reactions with various nucleophilic groups in tissue components, causing radiomimetic effects such as growth inhibition, cytotoxicity and mutagenicity. In addition SO has been classified as carcinogenic in animals and is probably carcinogenic in humans. Its detoxification may occur due to glutathione S-transferase (GST) catalysed conjugation with cytosolic glutathione. As peopleworking in a number of industries are exposed to styrene and SO, it is important to examine the role of glutathione conjugation versus other competing detoxication pathways. Similar studies have often been hampered by the lack of reliable

Název v anglickém jazyce

Study of cytosolic glutathione s-tranferase activity with styrene oxide by electromigration methods

Popis výsledku anglicky

Styrene-7,8-oxide is an industrial chemical used in the manufacture of epoxy resins; as an intermediate in the preparation of various agricultural chemicals, cosmetics and plastics; and in the processing of textile and fibres. SO is also the major cytochrome P450 metabolite of styrene, used in plastic and resin manufacture. As epoxide, SO is highly reactive and able to undergo reactions with various nucleophilic groups in tissue components, causing radiomimetic effects such as growth inhibition, cytotoxicity and mutagenicity. In addition SO has been classified as carcinogenic in animals and is probably carcinogenic in humans. Its detoxification may occur due to glutathione S-transferase (GST) catalysed conjugation with cytosolic glutathione. As peopleworking in a number of industries are exposed to styrene and SO, it is important to examine the role of glutathione conjugation versus other competing detoxication pathways. Similar studies have often been hampered by the lack of reliable

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA203%2F02%2F1447" target="_blank" >GA203/02/1447: Kapilární elektrochromatografie v lineárních a planárních mikrostrukturách s využitím polymerních náplní</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Book of abstract 14 th International Symposium on Capillary Electroseparation Techniques ITP 2004

ISBN

—

ISSN

—

e-ISSN

—

Počet stran výsledku

1

Strana od-do

32

Název nakladatele

Consiglio Nazionale delle Ricerche

Místo vydání

Řím

Místo konání akce

Řím Itálie

Datum konání akce

12. 9. 2004

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

—