Studium vztahu mezi metalothioneinem a tkými kovy pomocí chronopotenciometrické stripping analýzy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F04%3A00011227" target="_blank" >RIV/00216224:14310/04:00011227 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Study of relationship between metallothionein and heavy metals by chronopotentiometry stripping analysis

Popis výsledku v původním jazyce

The metallothionein (MT) is low molecular weight, intracellular and cysteine-rich proteins presenting high affinity for metal ions. Although the members of this family were discovered nearly 40 years ago, their functional significance remains obscure. MTs are involved in many pathophysiological processes such as metal ion homeostasis and detoxification, protection against oxidative damage, cell proliferation and apoptosis, chemoresistance and radiotherapy resistance. MT isoforms have been shown to be involved in several aspects of the carcinogenic process, cancer development and progression. MT expression has been implicated as a transient response to any form of stress or injury providing cytoprotective action. Although MT participates in the carcinogenic process and is used as a potential marker of tumor differentiation or cell proliferation, or as a predictor of poor prognosis remains unclear. Electrochemical measurements were performed with AUTOLAB Analyser (EcoChemie, Netherlands)

Název v anglickém jazyce

Study of relationship between metallothionein and heavy metals by chronopotentiometry stripping analysis

Popis výsledku anglicky

The metallothionein (MT) is low molecular weight, intracellular and cysteine-rich proteins presenting high affinity for metal ions. Although the members of this family were discovered nearly 40 years ago, their functional significance remains obscure. MTs are involved in many pathophysiological processes such as metal ion homeostasis and detoxification, protection against oxidative damage, cell proliferation and apoptosis, chemoresistance and radiotherapy resistance. MT isoforms have been shown to be involved in several aspects of the carcinogenic process, cancer development and progression. MT expression has been implicated as a transient response to any form of stress or injury providing cytoprotective action. Although MT participates in the carcinogenic process and is used as a potential marker of tumor differentiation or cell proliferation, or as a predictor of poor prognosis remains unclear. Electrochemical measurements were performed with AUTOLAB Analyser (EcoChemie, Netherlands)

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Chemistry

ISSN

0009-9147

e-ISSN

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Svazek periodika

50

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

ES - Španělské království

Počet stran výsledku

2

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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