Nejnovější poznatky z genetického výzkumu bolesti

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00013922" target="_blank" >RIV/00216224:14310/05:00013922 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

PAIN RESEARCH UPDATE FROM GENETIC POINT OF VIEW

Popis výsledku v původním jazyce

Molecular biology investigates the genetic causes of many diseases. Currently, molecular biology in pain research lags behind the investigations of the molecular basis of mental disorders. A significant challenge in pain genetic research is the fact thatpain involves emotional factors. Tools available for pain measurements and interindividual comparisons have been imperfect. Another problem relates to research ethics. Unlike animal studies, there is very limited ability to evoke experimental pain in agroup of humans with precisely defined age, sex, medication and pain experience. Nevertheless, pain investigations at the gene level have commenced. Recent progress in molecular biology has enabled gene expression modulations in animal models using knock-out, oligo-antisense and viral vector techniques. These methods enable investigation, at molecular level, as to which of the approximate 30 thousand genes of the human genome might be involved in pain mediation, which of these are polymo

Název v anglickém jazyce

PAIN RESEARCH UPDATE FROM GENETIC POINT OF VIEW

Popis výsledku anglicky

Molecular biology investigates the genetic causes of many diseases. Currently, molecular biology in pain research lags behind the investigations of the molecular basis of mental disorders. A significant challenge in pain genetic research is the fact thatpain involves emotional factors. Tools available for pain measurements and interindividual comparisons have been imperfect. Another problem relates to research ethics. Unlike animal studies, there is very limited ability to evoke experimental pain in agroup of humans with precisely defined age, sex, medication and pain experience. Nevertheless, pain investigations at the gene level have commenced. Recent progress in molecular biology has enabled gene expression modulations in animal models using knock-out, oligo-antisense and viral vector techniques. These methods enable investigation, at molecular level, as to which of the approximate 30 thousand genes of the human genome might be involved in pain mediation, which of these are polymo

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NM7146" target="_blank" >NM7146: Genetický podklad vnímání akutní bolesti</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pain Practice

ISSN

1530-7085

e-ISSN

—

Svazek periodika

5

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

341-348

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—