Disrupce signálování retinoidů 2,3,7,8-TCDD a ftaláty v buněčné linii P19/A15

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F05%3A00014611" target="_blank" >RIV/00216224:14310/05:00014611 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Disruption of retinoid signalling by 2,3,7,8-TCDD and phthalates on P19/A15 cell line

Popis výsledku v původním jazyce

Natural retinoids - vitamin A and its metabolites - are very important signalling molecules in eukaryotic organisms. They are necessary for vision, play an important role in cell growth, differenciation and apoptosis, influence embryonic development andfunction of nervous and immunity system, etc. In our study, we used an embryonic cell line P19/A15 stably transfected with luciferase gene under control of retinoic acid receptor (RAR) for investigation of effects of eight different phtalates and 2,3,7,8tetrachlorodibenzodioxin (TCDD) on retinoid signalling. Disruption of retinoid homeostasis as a result of exposure to dioxin-like substances has been described elsewhere. Furthermore, some studies suggested also direct downregulation of retinoid-dependent effects by TCDD. Phthalates widespread polutants released particularly from chemical industry have a similar structure to retinoids and for that reason we decided to investigate their possible interaction with retinoid pathway. P19/A15

Název v anglickém jazyce

Disruption of retinoid signalling by 2,3,7,8-TCDD and phthalates on P19/A15 cell line

Popis výsledku anglicky

Natural retinoids - vitamin A and its metabolites - are very important signalling molecules in eukaryotic organisms. They are necessary for vision, play an important role in cell growth, differenciation and apoptosis, influence embryonic development andfunction of nervous and immunity system, etc. In our study, we used an embryonic cell line P19/A15 stably transfected with luciferase gene under control of retinoic acid receptor (RAR) for investigation of effects of eight different phtalates and 2,3,7,8tetrachlorodibenzodioxin (TCDD) on retinoid signalling. Disruption of retinoid homeostasis as a result of exposure to dioxin-like substances has been described elsewhere. Furthermore, some studies suggested also direct downregulation of retinoid-dependent effects by TCDD. Phthalates widespread polutants released particularly from chemical industry have a similar structure to retinoids and for that reason we decided to investigate their possible interaction with retinoid pathway. P19/A15

Druh

D - Stať ve sborníku

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Joint Conference of Scandinavian Society of Cell Toxicology and Estonian Society of Toxicology

ISBN

9949-13-297-5

ISSN

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e-ISSN

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Počet stran výsledku

1

Strana od-do

61-61

Název nakladatele

SSCT-EST

Místo vydání

Tallinn

Místo konání akce

Toila, Estonsko

Datum konání akce

20. 10. 2005

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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