Gen pro interleukin 6: kandidátní gen neuropsychiatrických chorob?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00017435" target="_blank" >RIV/00216224:14310/06:00017435 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The gene for interleukin 6: the candidate gene for neuropsychiatric illness?

Popis výsledku v původním jazyce

IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objectivewas to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p&lt;0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p&lt;0.001) between controlsand ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship betw

Název v anglickém jazyce

The gene for interleukin 6: the candidate gene for neuropsychiatric illness?

Popis výsledku anglicky

IL-6 plays the role as a physiological neuromodulator involved in dopaminergic, serotonergic and other neurotransmissions. Genetic variation (-174 G/C polymorphism) in the promoter region of the IL-6 gene influences the expression of IL-6. Our objectivewas to determine whether -174 G/C polymorphism of IL-6 is associated with alcoholism and ADHD. In our two independent association studies, we investigated the relationship between above mentioned polymorphism and alcoholism in 400 alcoholics and 400 controls, and in ADHD study in 49 hyperactive boys and 40 control boys. We found a statistically significant difference (p&lt;0.03) in allelic frequencies between alcoholics and controls and statistically significant difference (p&lt;0.001) between controlsand ADHD subjects using Fisher exact test. The C allele was observed more frequently in alcoholics, as well as in ADHD group of boys in comparing with control subjects. Our association studies provided new data about the relationship betw

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NR8137" target="_blank" >NR8137: Molekulární příčiny dispozic ke vzniku alkoholizmu.</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Medical Genetics

ISSN

1552-4841

e-ISSN

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Svazek periodika

141B

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

728

Kód UT WoS článku

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EID výsledku v databázi Scopus

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