Variable temperature NMR studies on tautomerism of purine derivatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00018258" target="_blank" >RIV/00216224:14310/06:00018258 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Variable temperature NMR studies on tautomerism of purine derivatives

Popis výsledku v původním jazyce

Purine derivatives such as adenine is known to have several tautomeric forms. In their studies low temperature NMR has shown to be a useful tool. Tautomeric equilibria of purine and its derivatives is very important for their significant biological activities - antitumor and antiviral properties. As continuation of our previous studies we have done systematic multinuclear magnetic resonance investigations for several aminopurines in order to determine their tautomeric preferences. Tautomerism was studied in purine, 2,6-diaminopurine, 6-furfurylaminopurine, 6-mercaptopurine and 6-benzylaminopurine in DMF-d7 and MeOD-d4 at low temperatures by NMR spectroscopy.

Název v anglickém jazyce

Variable temperature NMR studies on tautomerism of purine derivatives

Popis výsledku anglicky

Purine derivatives such as adenine is known to have several tautomeric forms. In their studies low temperature NMR has shown to be a useful tool. Tautomeric equilibria of purine and its derivatives is very important for their significant biological activities - antitumor and antiviral properties. As continuation of our previous studies we have done systematic multinuclear magnetic resonance investigations for several aminopurines in order to determine their tautomeric preferences. Tautomerism was studied in purine, 2,6-diaminopurine, 6-furfurylaminopurine, 6-mercaptopurine and 6-benzylaminopurine in DMF-d7 and MeOD-d4 at low temperatures by NMR spectroscopy.

Druh

O - Ostatní výsledky

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů