"Lock and key" recognition in the world of protein-RNA interactions: How ADAR2 binds RNA

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00018577" target="_blank" >RIV/00216224:14310/06:00018577 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

"Lock and key" recognition in the world of protein-RNA interactions: How ADAR2 binds RNA

Popis výsledku v původním jazyce

The association of RNA-binding proteins with RNA transcript begins during transcription. Some of these early-binding proteins remain bound to RNA until it is degraded whereas others recognize and transiently bind to RNA during its maturation for specificprocesses such as splicing, processing, transport and localization. Some RNA-binding proteins function as RNA chaperones by helping the RNA, which is initially single-stranded, to form various secondary and tertiary structures. When folded these structured RNAs together with specific RNA sequences act as a signal for gene regulation. Adenosine deaminase that acts on RNA (ADAR) is a gene regulator that site-selectively modifies adenosines to inosines within RNA transcripts, thereby recoding genomic information. ADAR selects its substrate for deamination through recognition of certain double-helical irregularities within folded RNA transcript. This recognition is mediated using double-stranded RNA-binding motifs (dsRBMs) of ADAR. It will

Název v anglickém jazyce

"Lock and key" recognition in the world of protein-RNA interactions: How ADAR2 binds RNA

Popis výsledku anglicky

The association of RNA-binding proteins with RNA transcript begins during transcription. Some of these early-binding proteins remain bound to RNA until it is degraded whereas others recognize and transiently bind to RNA during its maturation for specificprocesses such as splicing, processing, transport and localization. Some RNA-binding proteins function as RNA chaperones by helping the RNA, which is initially single-stranded, to form various secondary and tertiary structures. When folded these structured RNAs together with specific RNA sequences act as a signal for gene regulation. Adenosine deaminase that acts on RNA (ADAR) is a gene regulator that site-selectively modifies adenosines to inosines within RNA transcripts, thereby recoding genomic information. ADAR selects its substrate for deamination through recognition of certain double-helical irregularities within folded RNA transcript. This recognition is mediated using double-stranded RNA-binding motifs (dsRBMs) of ADAR. It will

Druh

A - Audiovizuální tvorba

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

USA

Název nakladatele resp. objednatele

xxx

Verze

xxx

Identifikační číslo nosiče

N/A