Dva kandidátní DNA polymorfizmy u dětí s ADHD: asociační studie genů pro COMT a MAOB

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00018875" target="_blank" >RIV/00216224:14310/06:00018875 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Popis výsledku v původním jazyce

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It iswell known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD.Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the associa

Název v anglickém jazyce

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Popis výsledku anglicky

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It iswell known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD.Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the associa

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

<a href="/cs/project/NF6520" target="_blank" >NF6520: Klinické a molekulárně-biologické koreláty hyperkinetické poruchy v dětském věku</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Archives of Medical Science

ISSN

1734-1922

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

5

Strana od-do

235-239

Kód UT WoS článku

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EID výsledku v databázi Scopus

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