Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00019133" target="_blank" >RIV/00216224:14310/07:00019133 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines
Popis výsledku v původním jazyce
Nestin (intermediate filament class VI protein) is expressed in proliferating neuroepithelium during the development of mammalian CNS as well as in human and rodent neural stem cells and cell lines. In the adult CNS, nestin is detectable only in stem cells of the subventricular zone and partly in the choroid plexus. Our study was aimed at the nestin expression in cell lines derived from different types of solid tumors both in children and adults. Using immunodetection methods, nestin expression has beenshown in tissue sections and cell lines derived from neuroectodermal tumors (glioblastoma multiforme, neuroblastoma), as well as from malignant fibrose histiocytoma and osteosarcoma. We also focused on the subcellular localization of nestin in the celllines as described above. Our results brought the direct evidence of the nestin occurrence in cell nucleus in cell lines derived from neuroblastoma and glioblastoma multiforme.
Název v anglickém jazyce
Nestin as a biomarker of transformed cells in solid tumors and tumor cell lines
Popis výsledku anglicky
Nestin (intermediate filament class VI protein) is expressed in proliferating neuroepithelium during the development of mammalian CNS as well as in human and rodent neural stem cells and cell lines. In the adult CNS, nestin is detectable only in stem cells of the subventricular zone and partly in the choroid plexus. Our study was aimed at the nestin expression in cell lines derived from different types of solid tumors both in children and adults. Using immunodetection methods, nestin expression has beenshown in tissue sections and cell lines derived from neuroectodermal tumors (glioblastoma multiforme, neuroblastoma), as well as from malignant fibrose histiocytoma and osteosarcoma. We also focused on the subcellular localization of nestin in the celllines as described above. Our results brought the direct evidence of the nestin occurrence in cell nucleus in cell lines derived from neuroblastoma and glioblastoma multiforme.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
FD - Onkologie a hematologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NR9125" target="_blank" >NR9125: Diagnostický a prediktivní význam molekulárně cytogenetických markerů u embryonálních nádorů dětského věku.</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2007
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů