Interference of N-heterocyclic PAHs with signaling of retinoids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00020348" target="_blank" >RIV/00216224:14310/07:00020348 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Interference of N-heterocyclic PAHs with signaling of retinoids

Popis výsledku v původním jazyce

N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potenciesand bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed andquantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.

Název v anglickém jazyce

Interference of N-heterocyclic PAHs with signaling of retinoids

Popis výsledku anglicky

N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potenciesand bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed andquantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.

Druh

O - Ostatní výsledky

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

—

Projekt

<a href="/cs/project/GP525%2F05%2FP160" target="_blank" >GP525/05/P160: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů