Výskyt hlavních genetických markerů u multiformního glioblastomu je nezávislý na topologii nádoru

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F07%3A00022094" target="_blank" >RIV/00216224:14310/07:00022094 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology

Popis výsledku v původním jazyce

Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of adult primary brain tumor of astrocytic origin. GBM is characterized by a high degree of intratumoral heterogeneity both in histomorphology and genetic changes. Nevertheless, trisomy/polysomy of chromosome 7, monosomy of chromosome 10, EGFR gene amplification and p53 deletion have been described as the typical genetic markers for tumor classification and prediction of possible response to therapy. Our work was basedon detection of these four main genetic changes both in central and peripheral parts of the tumors to evaluate possible differences in the topological incidence of these genetic markers. Chromosomal abnormalities in tumor samples from a group of 21 patients surgically treated for GBM were characterized by means of the interphase-fluorescence in situ hybridization (I-FISH) technique using sets of centromere and locus-specific DNA probes. In addition, we performed a detailed analysis of on

Název v anglickém jazyce

Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology

Popis výsledku anglicky

Glioblastoma multiforme (GBM) is the most common as well as the most aggressive type of adult primary brain tumor of astrocytic origin. GBM is characterized by a high degree of intratumoral heterogeneity both in histomorphology and genetic changes. Nevertheless, trisomy/polysomy of chromosome 7, monosomy of chromosome 10, EGFR gene amplification and p53 deletion have been described as the typical genetic markers for tumor classification and prediction of possible response to therapy. Our work was basedon detection of these four main genetic changes both in central and peripheral parts of the tumors to evaluate possible differences in the topological incidence of these genetic markers. Chromosomal abnormalities in tumor samples from a group of 21 patients surgically treated for GBM were characterized by means of the interphase-fluorescence in situ hybridization (I-FISH) technique using sets of centromere and locus-specific DNA probes. In addition, we performed a detailed analysis of on

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/OC%20B19.001" target="_blank" >OC B19.001: Genová diagnostika a terapie multiformního glioblastomu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neoplasma

ISSN

0028-2685

e-ISSN

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Svazek periodika

54

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

212-218

Kód UT WoS článku

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EID výsledku v databázi Scopus

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