Syntézy, strukturní charakterizace a antiradikálové a antidiabetické aktivity měďnatých a zinečnatých komplexů Schiff. bazí odvozených od salicylaldehydu and beta-alaninu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00026162" target="_blank" >RIV/00216224:14310/08:00026162 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/08:00005483 RIV/62157124:16370/08:00002017

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine

Popis výsledku v původním jazyce

A series of copper(II) and zinc(II) complexes involving a tridentate 0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2),and [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes I and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80 K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in thecase of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.

Název v anglickém jazyce

Synthesis, structural characterization, antiradical and antidiabetic activities of copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and beta-alanine

Popis výsledku anglicky

A series of copper(II) and zinc(II) complexes involving a tridentate 0,N,O'-donor Schiff base derived from salicylaldehyde and P-alanine I i.e. N-salicylidene-beta-alanine(2-), (L)), having the composition [Cu-2(L)(2)(H2O)].H2O (1), [Cu(L)(H2O)](n) (2),and [Zn(L)(H2O)](n) (3), have been prepared and characterized by elemental analyses, UV-visible (UV-VIS), FT-IR and ESI-MS spectra, and thermal analyses. Complexes I and 2 have been investigated by single crystal X-ray analysis and also by temperature dependent magnetic susceptibility measurements (294-80 K). All prepared complexes have been evaluated by the antiperoxynitrite activity assay and alloxan-induced diabetes model. The significant antioxidant and antidiabetic activities have been found in thecase of both copper(II) complexes 1 and 2. In spite of first two complexes, the zinc(II) complex 3, as well as the potassium salt of the ligand (KHL) showed only insignificant protective effect against the tyrosine nitration in vitro.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CA - Anorganická chemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

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Svazek periodika

102

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

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Kód UT WoS článku

000255131500001

EID výsledku v databázi Scopus

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