Web server to identify similarity of amino acid motifs to compounds (SAAMCO)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F08%3A00056467" target="_blank" >RIV/00216224:14310/08:00056467 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Web server to identify similarity of amino acid motifs to compounds (SAAMCO)

Popis výsledku v původním jazyce

Protein-protein interactions are fundamental in mediating biological processes including metabolism, cell growth and signalling. To be able to selectively inhibit or induce protein activity or complex formation is a key feature in controlling disease. For those situations in which protein-protein interactions derive substantial affinity from short linear peptide sequences, or motifs, we can develop search algorithms for peptidomimetic compounds that resemble the short peptide?s structure but are not compromised by poor pharmacological properties. SAAMCO is a web service that facilitates the screening of motifs with known structures against bioactive compound databases. It is built on an algorithm that defines compound similarity based on the presence of appropriate amino acid side chain fragments and a favourable Root Mean Squared Deviation (RMSD) between compound and motif structure.

Název v anglickém jazyce

Web server to identify similarity of amino acid motifs to compounds (SAAMCO)

Popis výsledku anglicky

Protein-protein interactions are fundamental in mediating biological processes including metabolism, cell growth and signalling. To be able to selectively inhibit or induce protein activity or complex formation is a key feature in controlling disease. For those situations in which protein-protein interactions derive substantial affinity from short linear peptide sequences, or motifs, we can develop search algorithms for peptidomimetic compounds that resemble the short peptide?s structure but are not compromised by poor pharmacological properties. SAAMCO is a web service that facilitates the screening of motifs with known structures against bioactive compound databases. It is built on an algorithm that defines compound similarity based on the presence of appropriate amino acid side chain fragments and a favourable Root Mean Squared Deviation (RMSD) between compound and motif structure.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LC06030" target="_blank" >LC06030: Biomolekulární centrum</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chemical Information and Modeling

ISSN

1549-9596

e-ISSN

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Svazek periodika

48

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

1524-1529

Kód UT WoS článku

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EID výsledku v databázi Scopus

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