Architecture and activities of Structure Maintenance of Chromosome SMC5/6 complex
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00028719" target="_blank" >RIV/00216224:14310/09:00028719 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Architecture and activities of Structure Maintenance of Chromosome SMC5/6 complex
Popis výsledku v původním jazyce
SMC complexes (Structural Maintenance of Chromosomes)contribute to organization and maintenance of chromatin structure. SMC1/3 cohesin complex holds sister chromatids untill the onset of anaphase. Condensin complex is essential for condensing intephase chromosomes prior a mitosis. The third SMC5/6 complex is multifunctional - participates in e.g. DNA repair. SMC5/6 contains the most subunits: e.g. Nse2 is a SUMO ligase and Nse3 subunit is a funding member of MAGE (melanoma antigen) family of proteins. More then 50 genes (and/or pseudogenes) comprise the MAGE superfamily in human genome. Most of them are expressed in specific cancer/testis manner. Although a little is known about their function all available data indicate their important role in regulation of cellular processes and cancer genesis.
Název v anglickém jazyce
Architecture and activities of Structure Maintenance of Chromosome SMC5/6 complex
Popis výsledku anglicky
SMC complexes (Structural Maintenance of Chromosomes)contribute to organization and maintenance of chromatin structure. SMC1/3 cohesin complex holds sister chromatids untill the onset of anaphase. Condensin complex is essential for condensing intephase chromosomes prior a mitosis. The third SMC5/6 complex is multifunctional - participates in e.g. DNA repair. SMC5/6 contains the most subunits: e.g. Nse2 is a SUMO ligase and Nse3 subunit is a funding member of MAGE (melanoma antigen) family of proteins. More then 50 genes (and/or pseudogenes) comprise the MAGE superfamily in human genome. Most of them are expressed in specific cancer/testis manner. Although a little is known about their function all available data indicate their important role in regulation of cellular processes and cancer genesis.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
CE - Biochemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/IAA501630902" target="_blank" >IAA501630902: Charakterizace MAGE proteinů: kofaktory E3 ubiquitin ligáz?</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2009
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů